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dc.contributor.authorMoghimi-Dehkordi, B
dc.contributor.authorSafaee, A
dc.contributor.authorZali, MR
dc.date.accessioned2018-08-26T09:32:55Z
dc.date.available2018-08-26T09:32:55Z
dc.date.issued2008
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/57443
dc.description.abstractBackground and aim: The incidence of colorectal cancer is increased in Iran in recent years and colorectal cancer is the fourth most common cancer in both sexes. The aim of this study is to define the prognostic factors in Iranian colorectal cancer patients using univariate and multivariate methods. Materials and methods: All patients with colorectal cancer diagnosis according to the pathology report that registered in our cancer registry center in the period between Jan 2002 until Jan 2007 were eligible for this study. These patients were followed up by telephone contact. The probability curves for survival were calculated according to the Kaplan - Meier method and compared by the Log-rank test. Multivariate analysis was carried out using the Cox proportional hazard model. Results: Of 1,138 cases, a survival information was available on 1,127 patients, 690 males (61.2%) and 437 females (38.8%). Mean survival time was 105.1 (CI: 95.1-115.1) months. The Kaplan - Meier method indicated that the 1, 3, 5, 7, 10, and 15 years of survival rates are 91.1%, 73.1%, 61.0%, 54.9%, 47.9%, and 25.9%, respectively. According to the univariate analysis, the factors influencing overall survival rate were the following: Type of first treatment, body mass index, marital status, tumor grade, extent of wall penetration, distant metastasis, regional lymph nodes metastasis, and pathologic stage of tumor. The following five variables were independent prognostic factors for survival as determined by multivariate analysis: tumor size, metastasis of tumor, body mass index, marital status, and grade of tumor. Conclusion: Our results showed that stage of tumor, distant metastasis, grade of tumor, and tumor size should be considered as the most important prognostic factors in colorectal cancer patients. é Springer-Verlag 2008.
dc.language.isoEnglish
dc.relation.ispartofInternational Journal of Colorectal Disease
dc.subjectarticle
dc.subjectbody mass
dc.subjectcancer grading
dc.subjectcancer patient
dc.subjectcancer registry
dc.subjectcancer staging
dc.subjectcolorectal cancer
dc.subjectconfidence interval
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectfollow up
dc.subjecthuman
dc.subjectIran
dc.subjectKaplan Meier method
dc.subjectlog rank test
dc.subjectlymph node metastasis
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmarriage
dc.subjectmultivariate analysis
dc.subjectoverall survival
dc.subjectpriority journal
dc.subjectprobability
dc.subjectprognosis
dc.subjectproportional hazards model
dc.subjectsurvival rate
dc.subjectsurvival time
dc.subjecttelephone
dc.subjecttumor volume
dc.subjectunivariate analysis
dc.subjectAdolescent
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectAsian Continental Ancestry Group
dc.subjectColorectal Neoplasms
dc.subjectDemography
dc.subjectFemale
dc.subjectHumans
dc.subjectIran
dc.subjectKaplan-Meiers Estimate
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPrognosis
dc.subjectProportional Hazards Models
dc.titlePrognostic factors in 1,138 Iranian colorectal cancer patients
dc.typeArticle
dc.citation.volume23
dc.citation.issue7
dc.citation.spage683
dc.citation.epage688
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.1007/s00384-008-0463-7


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