Prevalence and predictors of isolated postchallenge hyperglycemia in Tehran's urban population: Tehran Lipid and Glucose Study (TLGS)
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Background: To determine the prevalence and characteristics of subjects with isolated post challenge hyperglycemia (IPH) defined as fasting plasma glucose (FPG) <126 mg/dl and 2-hour plasma glucose (2h-PG) ?200 mg/dl. Methods: We evaluated data and results of Oral Glucose Tolerance Test (OGTT) from 9745 participants in Tehran Lipid and Glucose Study (5589 women and 4156 men) aged>20years, without previously diagnosed diabetes mellitus (DM). A logistic regression model for having IPH was developed among subjects with FPG<126mg/dl to predict. Results: The prevalence of IPH was 3.1% (n=302). 26.5% (n=80) of subjects with IPH had FPG<100mg/dl. The odds ratios for IPH were statistically significant for FPG?100mg/dl (OR=9.5; 95% CI: 7.1-12.5), age?40 years (OR=2.6; 95% CI: 1.8-3.7), triglycerides?200 mg/dl (OR=2.1; 95% CI: 1.6-2.7), hypertension (OR=2.0, 95% CI: 1.5-2.6) and abnormal waist circumference (females?80, males?90cm) (OR=1.9, 95%CI: 1.3-2.8). Conclusion: This analysis showed that in Tehran urban subjects with FPG<126 mg/dl, variables such as FPG?100 mg/dl, older age, hypertriglyceridemia, hypertension and abnormal waist circumference were significantly associated with higher likelihood of IPH; OGTT would hence be recommended in subjects with above mentioned characteristics.