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dc.contributor.authorHaerian, MS
dc.contributor.authorHaerian, BS
dc.contributor.authorMolanaei, S
dc.contributor.authorKosari, F
dc.contributor.authorSabeti, S
dc.contributor.authorBidari-Zerehpoosh, F
dc.contributor.authorAbdolali, E
dc.contributor.authorZali, MR
dc.date.accessioned2018-08-26T09:31:13Z
dc.date.available2018-08-26T09:31:13Z
dc.date.issued2016
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/56942
dc.description.abstractSeveral studies have investigated whether MTHFR rs1801133 polymorphism contributes to risk of colorectal cancer (CRC), however the results are inconclusive. Aim: The purpose of this study was to investigate this hypothesis in a case-control study and meta-analysis in Iranian population. Materials & methods: This polymorphism was genotyped in the 2421 subjects (46% CRC patients) from Tehran. Meta-analysis was performed for determining the risk effect size of this polymorphism on CRC. Results: Both case-control study and meta-analysis showed no association between rs1801133 and CRC risk or its features. Conclusion: This study failed to identify an association between the rs1801133 and susceptibility to CRC in Iranian population. © 2016 Future Medicine Ltd.
dc.language.isoEnglish
dc.relation.ispartofPharmacogenomics
dc.subjectmethylenetetrahydrofolic acid
dc.subjectadult
dc.subjectcancer risk
dc.subjectcase control study
dc.subjectcolorectal cancer
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectgenetic association
dc.subjectgenetic polymorphism
dc.subjectgenetic susceptibility
dc.subjectgenotype
dc.subjecthuman
dc.subjectIranian people
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectMTHFR gene
dc.subjectReview
dc.subjectrisk assessment
dc.subjectstatistical analysis
dc.subjectsystematic review (topic)
dc.titleMTHFR rs1801133 polymorphism and susceptibility to colorectal cancer in Iranian population: Evidence of a case-control study and meta-analysis
dc.typeArticle
dc.citation.volume17
dc.citation.issue17
dc.citation.spage1957
dc.citation.epage1965
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.2217/pgs-2016-0048


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