Show simple item record

dc.contributor.authorMohebbi, SR
dc.contributor.authorZali, N
dc.contributor.authorDerakhshan, F
dc.contributor.authorTahami, A
dc.contributor.authorMashayekhi, R
dc.contributor.authorAmini-Bavil-Olyaee, S
dc.contributor.authorZali, MR
dc.date.accessioned2018-08-26T09:02:13Z
dc.date.available2018-08-26T09:02:13Z
dc.date.issued2008
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/55073
dc.description.abstractTo identify hepatitis delta virus (HDV) genetic variability and its circulating genotypes amongst infected Iranian patients, 25 patients with positive anti-HDV status from different parts of Iran were enrolled in this cross-sectional study. A portion of the HDV delta antigen was amplified, sequenced, and subjected to molecular and phylogenetic analysis. Clinical features and virological markers were evaluated. HDV RNA could be detected in 88% of anti-HDV positive cases (22 patients) with chronic hepatitis B virus (HBV) infection and liver cirrhosis. Phylogenetic analysis revealed that all Iranian patients were infected by genotype I (clade 1) of HDV, supported by a high bootstrap value (100%, 1,000 replicates). All HDV-positive patients were coinfected with genotype D1 of HBV. No significant association was determined between demographic, clinical, and virological variables in the population studied. In conclusion, the present molecular epidemiology survey reveals that clade 1 of HDV is predominant among coinfected HBV patients in Iran. é 2008 Wiley-Liss, Inc.
dc.language.isoEnglish
dc.relation.ispartofJournal of Medical Virology
dc.subjecthepatitis delta antigen
dc.subjectvirus RNA
dc.subjectadult
dc.subjectaged
dc.subjectamino acid sequence
dc.subjectarticle
dc.subjectcarboxy terminal sequence
dc.subjectcladistics
dc.subjectclinical article
dc.subjectclinical feature
dc.subjectcontrolled study
dc.subjectdelta agent hepatitis
dc.subjectfemale
dc.subjectgenetic variability
dc.subjectgenotype
dc.subjecthepatitis B
dc.subjectHepatitis B virus
dc.subjectHepatitis delta virus
dc.subjecthuman
dc.subjectIran
dc.subjectliver cirrhosis
dc.subjectmale
dc.subjectmixed infection
dc.subjectmolecular epidemiology
dc.subjectnucleotide sequence
dc.subjectphylogeny
dc.subjectvirus typing
dc.subjectAmino Acid Sequence
dc.subjectCluster Analysis
dc.subjectEpidemiology, Molecular
dc.subjectGenotype
dc.subjectHepatitis Antibodies
dc.subjectHepatitis B, Chronic
dc.subjectHepatitis D
dc.subjectHepatitis delta Antigens
dc.subjectHepatitis Delta Virus
dc.subjectHumans
dc.subjectIran
dc.subjectMolecular Sequence Data
dc.subjectPhylogeny
dc.subjectReverse Transcriptase Polymerase Chain Reaction
dc.subjectSequence Alignment
dc.subjectSequence Analysis, DNA
dc.subjectSequence Homology
dc.subjectHepatitis B virus
dc.subjectHepatitis delta virus
dc.titleMolecular epidemiology of Hepatitis Delta Virus (HDV) in Iran: A preliminary report
dc.typeArticle
dc.citation.volume80
dc.citation.issue12
dc.citation.spage2092
dc.citation.epage2099
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.1002/jmv.21326


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record