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dc.contributor.authorHaerian, MS
dc.contributor.authorHaerian, BS
dc.contributor.authorMolanaei, S
dc.contributor.authorKosari, F
dc.contributor.authorSabeti, S
dc.contributor.authorBidari-zerehpoosh, F
dc.contributor.authorAbdolali, E
dc.date.accessioned2018-08-26T08:59:45Z
dc.date.available2018-08-26T08:59:45Z
dc.date.issued2017
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/54838
dc.description.abstractSeveral studies reported the potential role of the rs1447295 polymorphism in susceptibility to cancer. This variant located in the cancer susceptibility candidate 8 (CASC8) is a long noncoding RNA (lnRNA) gene and does not code protein. LnRNA transcripts play a potential regulatory role in the expression of key genes involved in multiple cellular pathways, including cell cycle, pluripotency, and immune response. The aim of this study is to evaluate this association with colorectal cancer (CRC) in a large case-control study of the Iranian population. After extraction of genomic DNA by the standard protocols, the rs1447295 was genotyped in 2416 subjects (46% patients). Results of this case-control demonstrated no significant association between the rs1447295 polymorphism and risk of CRC or its characteristics under allele or alternative genotype models. In conclusion, it is unlikely that the rs1447295 polymorphism is a risk variant for the development of CRC in Iranian population. é 2017 Elsevier B.V.
dc.language.isoEnglish
dc.relation.ispartofGene
dc.subjectgenomic DNA
dc.subjectlong untranslated RNA
dc.subjectCASC8 protein, human
dc.subjecttumor protein
dc.subjectadult
dc.subjectallele
dc.subjectArticle
dc.subjectcancer grading
dc.subjectcancer risk
dc.subjectcancer staging
dc.subjectcancer susceptibility candidate 8 gene
dc.subjectcase control study
dc.subjectcolorectal cancer
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectgene
dc.subjectgenetic association
dc.subjectgenetic risk
dc.subjectgenotype
dc.subjecthuman
dc.subjectIranian people
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmiddle aged
dc.subjectmodel
dc.subjectpriority journal
dc.subjectrisk assessment
dc.subjectsingle nucleotide polymorphism
dc.subjectaged
dc.subjectclinical trial
dc.subjectcolorectal tumor
dc.subjectgenetic association study
dc.subjectgenetic predisposition
dc.subjectgenetics
dc.subjectIran
dc.subjectmulticenter study
dc.subjectAdult
dc.subjectAged
dc.subjectCase-Control Studies
dc.subjectColorectal Neoplasms
dc.subjectFemale
dc.subjectGenetic Association Studies
dc.subjectGenetic Predisposition to Disease
dc.subjectHumans
dc.subjectIran
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectNeoplasm Proteins
dc.subjectPolymorphism, Single Nucleotide
dc.titleLack of association of CASC8 rs1447295 with colorectal cancer in Iranian population: A multicenter case-control study
dc.typeArticle
dc.citation.volume634
dc.citation.spage74
dc.citation.epage76
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.1016/j.gene.2017.08.042


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