Insulin resistance and ? cell function in patients with ?-thalassemia major
MetadataShow full item record
Iron overload is a common finding in chronically transfused ?-thalassemia major (?-TM) patients with possible effect on ? cell function and insulin resistance. In this study we aimed to evaluate glucose metabolism, insulin resistance and ? cell function in ?-TM patients. A total of 78 transfusion-dependant ?-TM patients and 40 age and sex matched normal children were included. Oral glucose tolerance tests (OGTT) were performed in all subjects. Fasting plasma insulin level, insulin resistance index (IRI) and ? cell function index (BFI) were also estimated. ?-Thalassemia major patients had significantly more abnormal OGTT than the control group. ?-Thalassemia major patients had significantly higher levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) fasting blood sugar and IRI than the control group. Findings between ?-thalassemia (?-thal) patients, with and without abnormal OGTT results, were also compared; ?-thal patients with abnormal OGTT had significantly higher duration of chelation therapy, serum ferritin levels, AST, ALT and increased IRI and decreased BFI in comparison to patients with normal OGTT. Abnormal glucose metabolism is common in ?-TM patients with chelation therapy and multiple transfusions which are attributable to impaired ? cells' function and increased insulin resistance. é 2015 Informa Healthcare USA, Inc.
Showing items related by title, author, creator and subject.
Relationship of serum resistin level with insulin resistance indices in non-diabetic and diabetic obese subjects Mohammadzadeh, G; Zarghami, N; Larijani, B (2007)Background: Resistin, an adipocyte secreted factor, has been suggested to link obesity with type 2 diabetes and insulin resistance in rodent models but its relevance to human diabetes remains uncertain. The aim of this ...
Mohammadzadeh, G; Zarghami, N; Bahrami, A; Larijani, B (2007)Background: Adiponectin is an adipose tissue-derived hormone that low levels of this hormone are associated with obesity, insulin resistance, and type 2 diabetes. The aim of this study was to compare the serum levels of ...
High dose of radioactive iodine per se has no effect on glucose metabolism in thyroidectomized rats Samadi, R; Ghanbari, M; Shafiei, B; Gheibi, S; Azizi, F; Ghasemi, A (2017)Purpose: Thyroid concentrates radioactive iodine by sodium-iodide symporter; this is used for treating hyperthyroidism and thyroid cancer. Pancreas expresses NIS and radioactive iodine uptake may damage pancreatic beta-cells ...