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dc.contributor.authorDastranjTabrizi, A
dc.contributor.authorMostafaGharabaghi, P
dc.contributor.authorSheikhzadehHesari, F
dc.contributor.authorSadeghi, L
dc.contributor.authorZamanvandi, S
dc.contributor.authorSarbakhsh, P
dc.contributor.authorGhojazadeh, M
dc.date.accessioned2018-08-26T08:57:40Z
dc.date.available2018-08-26T08:57:40Z
dc.date.issued2016
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/54598
dc.description.abstractBackground: Ovarian epithelial cancers are among the most lethal women's cancers. There is no doubt about the preventive role of oral contraceptive pills (OCPs) in development of ovarian cancers. But, there are limited numbers of studies to address the effect of these agents on the number of cortical inclusion cysts (CICs), their epithelial type and suppression of the metaplastic phenomenon by these pills. The aim of this study was to clarify the role of these agents in the prevention of these cyst formation and tubal metaplasia and also examine the mesenchymal-epithelial transition theory in this context by immunohistochemical methods. Methods: The representative section(s) of ovarian cortex from a total number of 201 consecutive total abdominal hysterectomy with bilateral or unilateral salpingo-oophorectomy specimens were examined for mean number of CICs and their epithelial type between two groups of the patients. Group A included the patients who were on oral contraceptive pills for more than 5 years. All of the subjects with other contraceptive methods or a history of less than 5 years contraceptive pills usage were stratified in group B. Sections from 20 cases in which more than five inclusion cysts were found, were selected for IHC staining with calretinine and PAX8 as markers for mesothelium and mullerian epithelium respectively. Results: The mean age of the patients was 51.67 years with no significant differences between two groups. The mean number of cysts were 1.27 and 3.23 in group A and B respectively (P =0.0001). Similarly the mean number of CICs, lined by tubal epithelium, was significantly different between two groups (0.65 vs 2.65, P =0.0001). In IHC staining 123 out of 150 CICs (82 %) were PAX+ while only 7 CICs (4.8 %) showed positive reaction for calretinin irrespective of type of epithelium. Conclusion: Our findings showed that the use of OCP for more than five years in women, significantly prevents development of cortical inclusion cysts in the ovaries which lined by tubal (PAX8 positive) type epithelium. These findings may explain the alternative mechanism of oral contraceptive pills or long time use of progesterone in suppression of tubal type overgrowth and subsequently prevention of ovarian epithelial cancers. آ© 2016 DastranjTabrizi et al.
dc.language.isoEnglish
dc.relation.ispartofDiagnostic Pathology
dc.subjectCALB2 protein, human
dc.subjectcalretinin
dc.subjectoral contraceptive agent
dc.subjectpaired box transcription factor
dc.subjectPAX8 protein, human
dc.subjecttranscription factor PAX8
dc.subjectadult
dc.subjectaged
dc.subjectchemistry
dc.subjectdrug administration
dc.subjectdrug effects
dc.subjectepithelial mesenchymal transition
dc.subjectepithelium cell
dc.subjectFallopian tube
dc.subjectfemale
dc.subjecthuman
dc.subjectimmunohistochemistry
dc.subjectmetaplasia
dc.subjectmiddle aged
dc.subjectNeoplasms, Glandular and Epithelial
dc.subjectOvarian Cysts
dc.subjectOvarian Neoplasms
dc.subjectovary
dc.subjectpathology
dc.subjectphenotype
dc.subjecttumor microenvironment
dc.subjectAdult
dc.subjectAged
dc.subjectCalbindin 2
dc.subjectCellular Microenvironment
dc.subjectContraceptives, Oral, Hormonal
dc.subjectDrug Administration Schedule
dc.subjectEpithelial Cells
dc.subjectEpithelial-Mesenchymal Transition
dc.subjectFallopian Tubes
dc.subjectFemale
dc.subjectHumans
dc.subjectImmunohistochemistry
dc.subjectMetaplasia
dc.subjectMiddle Aged
dc.subjectNeoplasms, Glandular and Epithelial
dc.subjectOvarian Cysts
dc.subjectOvarian Neoplasms
dc.subjectOvary
dc.subjectPaired Box Transcription Factors
dc.subjectPAX8 Transcription Factor
dc.subjectPhenotype
dc.titleImpact and mechanistic role of oral contraceptive pills on the number and epithelial type of ovarian cortical inclusion cysts; a clinicopathology and immunohistochemical study
dc.typeArticle
dc.citation.volume11
dc.citation.issue1
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.1186/s13000-016-0482-6


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