Evaluation of platelet-rich plasma gel potential in acceleration of wound healing duration in patients underwent pilonidal sinus surgery: A randomized controlled parallel clinical trial
Malek Mohammadi, A
Zahed Panah, M
MetadataShow full item record
Objectives One of the most important surgical issues applied in the treatment of pilonidal sinus disease is wound healing. The aim of this study was to investigate the possible effect of platelet-rich plasma (PRP) gel on accelerating wound healing in these patients. Methods In this randomized, controlled, parallel group clinical trial, 110 patients were randomly allocated into two parallel groups with the same size (controls and treatment arm) after meeting inclusion and exclusion criteria. After the surgery, controls were treated by classic wound dressing while the case group was treated with PRP gel in a classic wound dressing platform. The patients were then evaluated for duration of antibiotics consumption, experienced pain and the time of returning to routine activities. Also, both groups were assessed for angiogenesis (by detecting CD34+ cells using immunohistochemical assay) and collagen sedimentation (masson's trichrome staining) using pre-complete healing wound biopsy. All the statistical analyses were performed using SPPS 20 and p-values of less than 0.05 considered statically significant. Results According to the results, patients treated with PRP gel went through a significantly faster healing process (8.69آ آ±آ 1.18 in controls and 4.78آ آ±آ 0.87 weeks in PRP gel treated ones with the P-valueآ =آ 0.03) and returned to their routine activities (3.3آ آ±آ 0.64 for the treatment of arm and 6.5آ آ±آ 1.03 weeks for controls with the P-valueآ =آ 0.00) while experiencing less pain (P-valueآ =آ 0.00) and shorter anti-biotic consumption duration (P-valueآ =آ 0.00). Conclusion Considering the results, authors of this study suggest PRP gel treatment for post operation wound dressing of pilonidal sinus disease with healing by secondary intention. é 2017 Elsevier Ltd
Showing items related by title, author, creator and subject.
Clinical application of oral form of ANGIPARS™ and in combination with topical form as a new treatment for diabetic foot ulcers: A randomized clinical trial Bahrami, A; Kamali, K; Ali-Asgharzadeh, A; Hosseini, P; Heshmat, R; Khorram Khorshid, HR; Gharibdoust, F; Madani, SH; Larijani, B (2008)ANGIPARS™ is a new herbal extract which has been produced in oral, topical, and intravenous forms. The present article contains preliminary results of the study which was planned to evaluate the efficacy and safety of ...
Zadeh Farahani, RM; Tubbs, RS; Shoja, MM (2008)[No abstract available]
Effects of intravenous Semelil (ANGIPARS™) on diabetic foot ulcers healing: A multicenter clinical trial Larijani, B; Heshmat, R; Bahrami, A; Delshad, H; Ranjbar Omrani, G; Mohammad, K; Heidarpour, R; Mohajeri Tehrani, MR; Kamali, K; Farhadi, M; Gharibdoust, F; Madani, SH (2008)Some diabetic foot ulcers, which are notoriously difficult to cure, are one of the most common health problems in diabetic patients .There are several surgical and medical options which already have been introduced for ...