Evaluation of chemotherapy toxicity in acute lymphoblastic and Myelogenous Leukemia
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Background and Aims: Adverse drug reactions (ADRs) are one of the major leading causes of death in the world. This study was designed and conducted because of the importance of adverse events in the cancer treatment setting and regarding this issue there is no study exploring adverse reactions of acute hematologie malignancy chemotherapy in Iranian population. Methods: This was a prospective, cross-sectional study performed at hematology-oncology and bone marrow transplantation research center. The inclusion criteria were all patients with acute hematologie malignancies such as ALL and AML, which were admitted over an 8 months period and were >15 years old age. Each ADR was categorized based on the WHO system organ classification. Results and Conclusion: The total number of detected ADRs was 310 in total of 105 patients. Eight patients (7.6%) experienced only one ADR, eleven patients (10.5%) experienced two ADRs and eighty-six of them (82%) experienced more than two ADRs. there was a significant relationship between the number of ADRs and type of hematologie malignancy. In this regard, the patients with AML malignancy showed more number of ADRs than with ALL malignancy (p<0.05) The Gastro-intestinal system disorders were the most common affected system-organ by chemotherapy regimens (33.5%). We suggest more well designed studies to determine the relation between the number of ADRs and study factors.
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