Effects of an oral supplementation of germinated barley foodstuff on serum tumour necrosis factor-?, interleukin-6 and -8 in patients with ulcerative colitis
MetadataShow full item record
Background: The efficacy of germinated barley foodstuff (GBF) on tumour necrosis factor-alpha (TNF-?), interleukin-6 (IL-6) and -8 (IL-8) in patients with ulcerative colitis (UC) has not yet been examined. The aim of the present study was to determine the effect of administration of GBF on serum TNF-?, IL-6 and -8 levels in UC patients in remission. Methods: Forty-one patients with UC were divided into two groups, namely control and GBF group. Twenty-one patients in the control group received standard treatment while 20 patients in the GBF group received 30 g of GBF daily by oral administration during two months of the study along with standard drug therapy. Results: Levels of TNF-?, IL-6 and -8 all decreased in the GBF group compared with baseline during the two-month study, while in the control group all values rose. For IL-6 and -8 this effect was significant, P = 0.034 and 0.013, respectively. Conclusions: The results of the present study showed that the consumption of GBF may reduce the level of serum TNF-?, IL-6 and -8 in patients with UC. This investigation was designed as a pilot study and the results may provide a basis for more future clinical trials.
Showing items related by title, author, creator and subject.
Vaghef-Mehrabany, E; Rad, AH; Alipour, B; Vaghef-Mehrabany, L; Asl, MS (2018)Background: Probiotics are live microorganisms with immune-regulatory properties and may be useful for patients suffering from rheumatoid arthritis (RA), an autoimmune inflammatory disorder. The aim of the present study ...
Mohammadian, M; Shamsasenjan, K; Nezhad, PL; Talebi, M; Jahedi, M; Nickhah, H; Minayi, N; Movassaghpour, A (2013)MSCs are multipotent progenitors which reside in bone marrow. They support hematopoietic stem cells homing, self renewal and differentiation in bone marrow. They can also differentiate into osteoblasts, adipocytes, ...
Th1 and Th2 cytokine gene expression in the peripheral blood of breast cancer patients compared to controls Tashnizi, AH; Habibagahi, M; Majidi, J; Razmkhah, M; Talei, A; Ghaderi, A; Jaberipour, M (2014)Background: Cytokines produced by different subsets of T cells are the key mediators to adjust the quality of immune responses. Despite evidence of induction of an immune reaction against tumors such as breast cancer, not ...