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dc.contributor.authorNahandi, MZ
dc.contributor.authorKhoshbaten, M
dc.contributor.authorRamazanzadeh, E
dc.contributor.authorAbbaszadeh, L
dc.contributor.authorJavadrashid, R
dc.contributor.authorShirazi, KM
dc.contributor.authorGholami, N
dc.date.accessioned2018-08-26T08:52:33Z
dc.date.available2018-08-26T08:52:33Z
dc.date.issued2014
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/53749
dc.description.abstractAim: This study aimed to evaluate the effect of NAFLD on CIMT as a risk factor for atherosclerosis. Background: The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide due to rise of obesity and diabetes mellitus (DM) prevalence. Non-invasive assessment of carotid intima-media thickness (CIMT) by high-resolution carotid B-mode ultrasonography is widely used for determining the atherosclerosis. Patients and methods: In this case-control setting, 151 subjects were categorized in three groups: group I including 49 patients with NAFLD and DM; group II including 50 non-diabetic NAFLD patients; and the control including 52 normal subjects as group III. The right and left CIMTs and its maximum reading (CIMTmax) were measured by a skilled sonographist blind to the groups. The sonographic grading of the NAFLD was determined in group I and II. Results: Median CIMTmax was significantly higher in group I comparing with group II and control group (p<0.001). This difference between group I and group II was not significant after adjusting for age and history of hypertension and hyperlipidemia (p=0.089). After controlling the confounders, there was statistical significant between group I and group II with the control group (p<0.05). There was no significant difference in median maximal thickness of intima-media in the carotid of group I compare to group II in patients with and without elevated liver enzymes (in both groups, 0.6 mm, p= 0.402). Conclusion: Based on our findings, there is a significant association between the presence of NAFLD and atherosclerosis. This association was independent to the DM presence. The grade of NAFLD and elevated liver function tests had no effect on severity of atherosclerosis. © 2014 RIGLD, Research Institute for Gastroenterology and Liver Diseases.
dc.language.isoEnglish
dc.relation.ispartofGastroenterology and Hepatology from Bed to Bench
dc.subjectalanine aminotransferase
dc.subjectaspartate aminotransferase
dc.subjectglucose
dc.subjecthigh density lipoprotein
dc.subjecttriacylglycerol
dc.subjectadult
dc.subjectage distribution
dc.subjectalanine aminotransferase blood level
dc.subjectarterial wall thickness
dc.subjectarticle
dc.subjectaspartate aminotransferase blood level
dc.subjectatherosclerosis
dc.subjectB scan
dc.subjectbody mass
dc.subjectcardiovascular risk
dc.subjectcase control study
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectdiabetes mellitus
dc.subjectdiabetic patient
dc.subjectdisease association
dc.subjectdisease classification
dc.subjectdisease severity
dc.subjectfemale
dc.subjectglucose blood level
dc.subjecthuman
dc.subjecthyperlipidemia
dc.subjecthypertension
dc.subjecthypertransaminasemia
dc.subjectlipoprotein blood level
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmedical history
dc.subjectnonalcoholic fatty liver
dc.subjectobesity
dc.subjectwaist circumference
dc.subjectwalking
dc.titleEffect of non-alcoholic fatty liver disease on carotid artery intimamedia thickness as a risk factor for atherosclerosis
dc.typeArticle
dc.citation.volume7
dc.citation.issue1
dc.citation.spage55
dc.citation.epage62
dc.citation.indexScopus


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