Drug utilization evaluation of cyclosporine in allogeneic hematopoietic stem cell transplantation
MetadataShow full item record
Objectives: The use of cyclosporine for graft-versushost disease prophylaxis is a major factor in successful allogeneic hematopoietic stem cell transplantation. However, despite the drug being in clinical practice for more than 3 decades, there is no current global and consistent protocol for its optimal method of administration. In this study, we recorded situations related to cyclosporine administration and associated adverse reactions to aid in the development of more precise future guidelines. Materials and Methods: We monitored 22 candidates for allogeneic stem cell transplant during their hospitalization for a 1-year period, acquiring data recorded from predefined questionnaires prepared according to accredited literature, which included daily clinical and laboratory examinations. Results: Despite active attempts toward adherence to a standard protocol for cyclosporine administration, we found numerous occasions of deviations or mistakes, which may have led to adverse reactions. Conclusions: Our study, as one of the first published "drug utilization evaluations" for cyclosporine in stem cell transplant setting, proposes that educating involved clinical staff regarding a standard method of cyclosporine administration and providing efficient facilities would be highly valuable to implementation of a better practice. é 2015, Ba?kent University.
Showing items related by title, author, creator and subject.
A testimony to the history of heart and lung transplantation: English translation of Demikhov's paper, "Transplantation of the Heart, Lungs and other Organs". Shoja, MM; Tubbs, RS; Ardalan, MR; Loukas, M; Phagava, H; Cohen-Gadol, AA (2010)Vladimir Petrovich Demikhov, a Soviet physiologist and surgeon, made meticulous attempts at reviving heart and lung transplantation in the last century. Herein, we present an English translation of Demikhov's 1969 paper ...
Ardalan, M; Etemadi, J; Ghabili, K; Ghojazadeh, M; Ghafari, A; Khosroshahi, HT (2011)Background: Peritoneal dialysis (PD) and Hemodialysis (HD) have been considered as two standard treatment methods in patients with end stage renal disease. It has been proposed that PD patients have a more protected volume ...
Evaluating successful achievement of therapeutic mycophenolate trough levels in kidney transplant patients receiving cyclosporine and tacrolimus during six month after transplantation Hatami, Shabnam (Tabriz University of Medical Sciences,Faculty of Pharmacy, 2019)Introduction: Kidney transplantation is the choiced treatment for chronic renal failure. Mycophenolate is an important drug in kidney transplantation and has a narrow therapeutic range. However, the role of monitoring of ...