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dc.contributor.authorKafshdooz, T
dc.contributor.authorArdabili, SMM
dc.contributor.authorKafshdooz, L
dc.contributor.authorTabrizi, AD
dc.contributor.authorGhojazadeh, M
dc.contributor.authorGharesouran, J
dc.contributor.authorAkbarzadeh, A
dc.date.accessioned2018-08-26T08:38:57Z
dc.date.available2018-08-26T08:38:57Z
dc.date.issued2015
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/52979
dc.description.abstractObjective: Endometrial cancer is the fourth most common cancer among women in developed countries. Affected patients may benefit from systemic chemotherapy, alone or in combination with targeted therapies if the disease is clinically diagnosed prior to expansion and metastasis to other organs.The aim of this study was to evaluate the prognostic role of c-kit mutations and comparision with tumor type and grade in human uterine endometrial carcinomas. Materials and Methods: Seventy five patients with endometrial carcinoma and seventy five normal controls were studied for possible mutations in exon 17 of the c-kit gene using single strand conformational polymorphisms and sequencing. Results: c-kit mutation in exon 17 appeared to be significantly different between endometrial carcinoma and normal endometrium. The pattern and frequency of the mutations was also shown to be different between tumors from different stages.
dc.language.isoEnglish
dc.relation.ispartofAsian Pacific Journal of Cancer Prevention
dc.subjectDNA
dc.subjectstem cell factor receptor
dc.subjectcancer grading
dc.subjectcancer staging
dc.subjectclassification
dc.subjectDNA sequence
dc.subjectendometrium
dc.subjectendometrium tumor
dc.subjectfemale
dc.subjectgene frequency
dc.subjectgenetic predisposition
dc.subjectgenetics
dc.subjecthuman
dc.subjectmiddle aged
dc.subjectnucleotide sequence
dc.subjectpathology
dc.subjectpolymerase chain reaction
dc.subjectprognosis
dc.subjectsingle strand conformation polymorphism
dc.subjectBase Sequence
dc.subjectDNA, Neoplasm
dc.subjectEndometrial Neoplasms
dc.subjectEndometrium
dc.subjectFemale
dc.subjectGene Frequency
dc.subjectGenetic Predisposition to Disease
dc.subjectHumans
dc.subjectMiddle Aged
dc.subjectNeoplasm Grading
dc.subjectNeoplasm Staging
dc.subjectPolymerase Chain Reaction
dc.subjectPolymorphism, Single-Stranded Conformational
dc.subjectPrognosis
dc.subjectProto-Oncogene Proteins c-kit
dc.subjectSequence Analysis, DNA
dc.titleC-kit mutations in endometrial cancer: Correlation with tumor histologic type
dc.typeArticle
dc.citation.volume16
dc.citation.issue17
dc.citation.spage7449
dc.citation.epage7452
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.7314/APJCP.2015.16.17.7449


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