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dc.contributor.authorHaghighi, MM
dc.contributor.authorMohebbi, SR
dc.contributor.authorSadeghi, RN
dc.contributor.authorVahedi, M
dc.contributor.authorGhiasi, S
dc.contributor.authorZali, MR
dc.date.accessioned2018-08-26T08:36:08Z
dc.date.available2018-08-26T08:36:08Z
dc.date.issued2008
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/52714
dc.description.abstractBackground: It has been proposed that folate and polymorphisms of the enzyme methylenetetrahydrofolate reductase (MTHFR), which regulates influx of folate for methylation reactions for DNA synthesis and repair, are involved in colorectal cancer. This study was designed to determine the influence of a genetic variant (MTHFR G1793A) and folate on colon cancer in Iran. Materials and Methods: We analyzed 227 cases and 239 normal unmatched controls using pyrosequencing. Odds ratios and 95% confidence intervals (95% CI) were calculated to evaluate associations of the MTHFR gene polymorphism with colorectal cancer risk. Results: A significantly reduced risk of recurrence was observed in patients heterozygous for the MTHFR G1793A polymorphism (OR: 0.17; 95% CI, 0.05- 0.52). The frequency of GG, GA and AA genotypes of MTHFR among the colorectal cancer patients were 98%, 2% and 0% respectively, while the frequencies among controls were 90%, 10% and 0%, respectively. Furthermore, a significant reduction in recurrence risk was seen in MTHFR G1793A heterozygotes limited to those who received folate supplements. Conclusion: Our study is compatible with previous findings concerning a reverse association between the MTHFR 1793G>A genotype with cancers in different populations.
dc.language.isoEnglish
dc.relation.ispartofAsian Pacific Journal of Cancer Prevention
dc.subjectmethylenetetrahydrofolate reductase (NADPH2)
dc.subjectage distribution
dc.subjectaged
dc.subjectarticle
dc.subjectcancer staging
dc.subjectcase control study
dc.subjectcolorectal tumor
dc.subjectconfidence interval
dc.subjectdeveloping country
dc.subjectenzymology
dc.subjectfemale
dc.subjectgene expression regulation
dc.subjectgenetic polymorphism
dc.subjectgenetic predisposition
dc.subjectgenetics
dc.subjectgenotype
dc.subjecthuman
dc.subjectincidence
dc.subjectIran
dc.subjectmale
dc.subjectmetabolism
dc.subjectmiddle aged
dc.subjectreference value
dc.subjectrisk
dc.subjectrisk assessment
dc.subjectsex ratio
dc.subjectsurvival
dc.subjecttumor recurrence
dc.subjectAge Distribution
dc.subjectAged
dc.subjectCase-Control Studies
dc.subjectColorectal Neoplasms
dc.subjectConfidence Intervals
dc.subjectDeveloping Countries
dc.subjectFemale
dc.subjectGene Expression Regulation, Neoplastic
dc.subjectGenetic Predisposition to Disease
dc.subjectGenotype
dc.subjectHumans
dc.subjectIncidence
dc.subjectIran
dc.subjectMale
dc.subjectMethylenetetrahydrofolate Reductase (NADPH2)
dc.subjectMiddle Aged
dc.subjectNeoplasm Recurrence, Local
dc.subjectNeoplasm Staging
dc.subjectOdds Ratio
dc.subjectPolymorphism, Genetic
dc.subjectReference Values
dc.subjectRisk Assessment
dc.subjectSex Distribution
dc.subjectSurvival Analysis
dc.titleAssociation between the 1793G>A MTHFR polymorphism and sporadic colorectal cancer in Iran
dc.typeArticle
dc.citation.volume9
dc.citation.issue4
dc.citation.spage659
dc.citation.epage662
dc.citation.indexScopus


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