Show simple item record

dc.contributor.authorHaghighi, MM
dc.contributor.authorRadpour, R
dc.contributor.authorMahmoudi, T
dc.contributor.authorMohebbi, SR
dc.contributor.authorVahedi, M
dc.contributor.authorZali, MR
dc.date.accessioned2018-08-26T08:36:05Z
dc.date.available2018-08-26T08:36:05Z
dc.date.issued2009
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/52708
dc.description.abstractThe enzyme 5,10-methylene-tetrahydrofolate reductase (MTHFR) is linked to DNA methylation, synthesis, and repair. C677T is one of the most important polymorphisms in the MTHFR gene. The single nucleotide polymorphism C677T has been found to be associated with decreased enzyme activity and plasma folate, and thus may play a crucial role in the etiology of colorectal cancer. This decrease was observable in people with either high or low folate status. We aimed to test the hypothesis that the C677T genotype is involved in colorectal cancer. Using pyrosequencing, we analyzed the MTHFR genotypes in 234 colorectal cancer patients and 257 matched controls. We examined the polymorphisms in MTHFR and folate intake in relation to risk of colon cancer in an Iranian population-based case-control study. Our finding revealed that the CC, CT, and TT genotypes of MTHFR among the colorectal cancer patients were 50%, 29.1%, and 20.9%, respectively. On the other hand, we could find 29.5% of 677CC, 46% of 677CT and 24.5% of 677TT in the controls. A decreased risk of colon cancer for participants with wild-type genotype was observed. Interestingly, this association was stronger at higher levels of folate intake. Our study corroborates previous findings of an inverse association of the MTHFR 677TT genotype with colorectal cancer, in particular at high levels of folate. Copyright é 2009 Cognizant Comm. Corp. All rights reserved.
dc.language.isoEnglish
dc.relation.ispartofOncology Research
dc.subject5,10 methylenetetrahydrofolate reductase (FADH2)
dc.subjectfolic acid
dc.subjectmethylenetetrahydrofolate reductase (NADPH2)
dc.subjectarticle
dc.subjectcancer patient
dc.subjectchild
dc.subjectcolorectal cancer
dc.subjectcontrolled study
dc.subjectdietary intake
dc.subjectDNA methylation
dc.subjectDNA repair
dc.subjectDNA synthesis
dc.subjectenzyme activity
dc.subjectfemale
dc.subjectgenetic association
dc.subjectgenotype
dc.subjecthuman
dc.subjecthuman cell
dc.subjectIran
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmthfr gene
dc.subjectoncogene
dc.subjectpriority journal
dc.subjectpyrosequencing
dc.subjectrisk reduction
dc.subjectsingle nucleotide polymorphism
dc.subjectwild type
dc.subjectaged
dc.subjectblood
dc.subjectcolorectal tumor
dc.subjectgenetic polymorphism
dc.subjectgenetics
dc.subjectmiddle aged
dc.subjectmolecular genetics
dc.subjectnucleotide sequence
dc.subjectAged
dc.subjectBase Sequence
dc.subjectColorectal Neoplasms
dc.subjectFemale
dc.subjectFolic Acid
dc.subjectGenotype
dc.subjectHumans
dc.subjectMale
dc.subjectMethylenetetrahydrofolate Reductase (NADPH2)
dc.subjectMiddle Aged
dc.subjectMolecular Sequence Data
dc.subjectPolymorphism, Genetic
dc.titleAssociation between MTHFR polymorphism (C677T) with nonfamilial colorectal cancer
dc.typeArticle
dc.citation.volume18
dc.citation.issue3
dc.citation.spage57
dc.citation.epage63
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.3727/096504009789954636


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record