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dc.contributor.authorMohseni, F
dc.contributor.authorFarhangi, MA
dc.contributor.authorFarajnia, S
dc.contributor.authorKhoshbaten, M
dc.contributor.authorAjourlou, E
dc.contributor.authorKakaei, F
dc.date.accessioned2018-08-26T08:33:30Z
dc.date.available2018-08-26T08:33:30Z
dc.date.issued2016
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/52437
dc.description.abstractThe current study evaluated the association between major components of Mediterranean dietary regimen with metabolic biomarkers and uncoupling protein-2 (UCP2)-866G/A gene polymorphism in patients with non-alcoholic fatty liver disease (NAFLD). In this study 75 patients with NAFLD and 76 healthy individuals were enrolled. Dietary intakes were assessed using a semi-quantitative food-frequency questionnaire (FFQ) and Mediterranean dietary quality index (Med-DQI) was calculated. Anthropometric assessments were performed; body mass index (BMI) and waist to hip ratio (WHR) were calculated. Biochemical assays including FSG (fasting serum glucose), liver enzymes and lipid profiles were measured. Polymorphism of-866G/A UCP2 gene was determined using polymerase chain reaction-restriction fragment length polymorphism method. Serum high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) concentrations were significantly lower and serum aspartate amino transferase (AST), alanine amino transferase (ALT) and triglyceride (TG) concentrations were significantly higher in NAFLD patients compared with control group (P < 0.05). NAFLD patients with higher intakes of "saturated fatty acids" and "cholesterol" had significantly higher serum TG, while patients with higher intakes of "olive" had lower serum TG and AST concentrations. According to -866A/G of UCP2 gene polymorphism between study groups, only the score of "meat" subgroup in NAFLD patients with GG genotype was higher compared with patients in other genotypes of UCP2 gene (P < 0.05). We observed a significant relationship between Mediterranean dietary quality index and metabolic risk factors. We also demonstrated a higher meat intake in GG genotype among these patients. Copyright آ© 2016 by New Century Health Publishers, LLC.
dc.language.isoEnglish
dc.relation.ispartofCurrent Topics in Nutraceutical Research
dc.subjectalanine aminotransferase
dc.subjectaspartate aminotransferase
dc.subjectbiological marker
dc.subjectcholesterol
dc.subjectglucose
dc.subjecthigh density lipoprotein cholesterol
dc.subjectlipid
dc.subjectliver enzyme
dc.subjectlow density lipoprotein cholesterol
dc.subjectolive oil
dc.subjectsaturated fatty acid
dc.subjecttriacylglycerol
dc.subjectuncoupling protein 2
dc.subjectadult
dc.subjectalanine aminotransferase blood level
dc.subjectanthropometry
dc.subjectArticle
dc.subjectaspartate aminotransferase blood level
dc.subjectbiochemical analysis
dc.subjectbody mass
dc.subjectcholesterol diet
dc.subjectclinical assessment tool
dc.subjectclinical evaluation
dc.subjectcontrolled study
dc.subjectcorrelation analysis
dc.subjectdietary intake
dc.subjectfemale
dc.subjectfood frequency questionnaire
dc.subjectgenetic polymorphism
dc.subjectgenotype
dc.subjectglucose blood level
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmeat
dc.subjectMediterranean diet
dc.subjectMediterranean dietary quality index
dc.subjectmetabolism
dc.subjectnonalcoholic fatty liver
dc.subjectnutrition
dc.subjectpatient compliance
dc.subjectpolymerase chain reaction
dc.subjectquantitative analysis
dc.subjectrestriction fragment length polymorphism
dc.subjectrisk factor
dc.subjecttriacylglycerol blood level
dc.subjectwaist hip ratio
dc.titleAdherence to Mediterranean nutrition pattern in patients with non-alcoholic fatty liver disease: Relationship with metabolic risk factors and -UCP2-866G/A gene polymorphisms
dc.typeArticle
dc.citation.volume14
dc.citation.issue1
dc.citation.spage49
dc.citation.epage57
dc.citation.indexScopus


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