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dc.contributor.authorShiroodi, MK
dc.contributor.authorShafiei, B
dc.contributor.authorBaharfard, N
dc.contributor.authorGheidari, ME
dc.contributor.authorNazari, B
dc.contributor.authorPirayesh, E
dc.contributor.authorKiasat, A
dc.contributor.authorHoseinzadeh, S
dc.contributor.authorHashemi, A
dc.contributor.authorAkbarzadeh, MA
dc.contributor.authorJavadi, H
dc.contributor.authorNabipour, I
dc.contributor.authorAssadi, M
dc.date.accessioned2018-08-26T08:31:55Z
dc.date.available2018-08-26T08:31:55Z
dc.date.issued2012
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/52223
dc.description.abstractRapid technetium-99 m methoxyisobutylisonitrile (99 mTc-MIBI) washout has been shown to occur in impairedmyocardia. This study is based on the hypothesis that scintigraphy can be applied to calculate the myocardial 99 mTc-MIBI washout rate (WR) to diagnose and evaluate heart failure severity and other left ventricular functional parameters specifically in idiopathic dilated cardiomyopathy (IDCM) patients. Patients with IDCMP (n = 17; 52.65 آ± 11.47 years) and normal subjects (n = 6; 49.67 آ± 10.15 years)were intravenously administered 99 mTc-hexakis-2-methoxyisobutylisonitrile (99 mTc-MIBI). Next, early and delayed planar data were acquired (at 3.5-h intervals), and electrocardiogram (ECG)-gated myocardial perfusion single photon emission computed tomography (SPECT) was performed. The 99 mTc-MIBI WR was calculated using early and delayed planar images. Left ventricular functional parameters were also analyzed using quantitative gated SPECT (QGS) data. In target group, myocardial WRs (29.13 آ± 6.68%) were significantly higher than those of control subjects (14.17 آ± 3.31%; P < 0.001). The 99 mTc-MIBI WR increased with the increasing severity of the NYHA functional class (23.16 آ± 1.72% for class I, 30.25 آ± 0.95%for class II, 32.60 آ± 6.73%for class III, and 37.50 آ± 7.77% for class IV; P = 0.02). The WR was positively correlated with the end-diastolic volume (EDV) index (r 2 = 0.216; ? = 0.464; P = 0.02 [ml/m 2], the end-systolic volume (ESV) index (r 2 = 0.234; ? = 0.484; P = 0.01 [ml/m 2]), the summed motion score (SMS) (r 2 = 0.544; ? = 0.738; P = 0.00), and the summed thickening score (STS) (r 2 = 0.656; ? = 0.810; P = 0.00); it was negatively correlated with the left ventricular ejection fraction (LVEF) (r 2 = 0.679; ? = -0.824; P = 0.00). It can be concluded that 99 mTc-MIBI scintigraphy might be a valuable molecular imaging tool for the diagnosis and evaluation of myocardial damage or dysfunction severity. آ© Springer Science+Business Media, B.V. 2010.
dc.language.isoEnglish
dc.relation.ispartofInternational Journal of Cardiovascular Imaging
dc.subjectmethoxy isobutyl isonitrile technetium tc 99m
dc.subjectmethoxy isobutyl isonitrile technetium tc 99m
dc.subjectradiopharmaceutical agent
dc.subjectadult
dc.subjectarticle
dc.subjectclinical article
dc.subjectcongestive cardiomyopathy
dc.subjectcontrolled study
dc.subjectdisease severity
dc.subjectelectrocardiogram
dc.subjectfemale
dc.subjectheart left ventricle ejection fraction
dc.subjectheart left ventricle enddiastolic pressure
dc.subjectheart left ventricle endsystolic volume
dc.subjectheart left ventricle function
dc.subjecthuman
dc.subjectimage analysis
dc.subjectmale
dc.subjectmyocardial perfusion imaging
dc.subjectradioactivity
dc.subjectsingle photon emission computer tomography
dc.subjectwashout rate
dc.subjectcardiac gated imaging
dc.subjectcongestive cardiomyopathy
dc.subjectelectrocardiography
dc.subjecthospitalization
dc.subjectmethodology
dc.subjectmiddle aged
dc.subjectnonparametric test
dc.subjectscintiscanning
dc.subjectCardiomyopathy, Dilated
dc.subjectElectrocardiography
dc.subjectFemale
dc.subjectGated Blood-Pool Imaging
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMyocardial Perfusion Imaging
dc.subjectRadiopharmaceuticals
dc.subjectSeverity of Illness Index
dc.subjectStatistics, Nonparametric
dc.subjectTechnetium Tc 99m Sestamibi
dc.subjectTomography, Emission-Computed, Single-Photon
dc.title99 mTc-MIBI washout as a complementary factor in the evaluation of idiopathic dilated cardiomyopathy (IDCM) using myocardial perfusion imaging
dc.typeArticle
dc.citation.volume28
dc.citation.issue1
dc.citation.spage211
dc.citation.epage217
dc.citation.indexScopus
dc.identifier.DOIhttps://doi.org/10.1007/s10554-010-9770-5


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