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dc.contributor.authorKhosroshahi, HT
dc.contributor.authorMogaddam, AN
dc.contributor.authorShoja, MM
dc.date.accessioned2018-08-26T06:34:02Z
dc.date.available2018-08-26T06:34:02Z
dc.date.issued2006
dc.identifier.urihttp://dspace.tbzmed.ac.ir:8080/xmlui/handle/123456789/43885
dc.description.abstractUrinary tract infection (UTI), a major cause of morbidity in renal transplant recipients, has also been found to increase mortality. The first month post-kidney transplantation is considered the critical time, with most UTI episodes during this period. The aim of this study was to compare the efficacy of various doses of trimethoprim-sulfamethoxazole (TMP/SXT) for the prophylaxis of the posttransplant UTI within the first month after kidney transplantation. In a prospective, double-blind, randomized, clinical trial, 95 kidney allograft recipients were divided into two groups: group 1 (n = 63) received low to moderate doses of TMP/SXT (either 80/400 mg or 160/800 mg, daily) and group 2 (n = 32), high doses of TMP/SXT (320/1600 mg, daily in two divided doses). These groups were comparable regarding age, gender, type of donor, and ureteral anastomosis and immunosuppressive therapy. UTI was defined as a urine culture containing more than 10(5) colonies. The mean age of the patients was 37 +/- 12.2 years with a male/female ratio of 0.98/1. The urine culture was positive in 39 patients (41.1%). UTI was more common among female than male patients (P = .003). Escherichia coli was the most common isolated organism in both groups (53.8%). UTI was observed in about 25% of patients on the high-dose versus 49.2% of those on low- to moderate-dose prophylaxis (P < .05). In conclusion, prophylaxis with high-dose TMP/SXT (320/1600 mg, daily) is preferred for renal transplant recipients during the first month posttransplantation.
dc.language.isoEnglish
dc.relation.ispartofTransplantation proceedings
dc.subjectAdult
dc.subjectAnti-Infective Agents
dc.subjectDose-Response Relationship, Drug
dc.subjectDouble-Blind Method
dc.subjectEscherichia coli Infections
dc.subjectFemale
dc.subjectHumans
dc.subjectIran
dc.subjectKidney Transplantation
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectPostoperative Complications
dc.subjectProspective Studies
dc.subjectTrimethoprim, Sulfamethoxazole Drug Combination
dc.subjectUrinary Tract Infections
dc.subjectUrine
dc.titleEfficacy of high-dose trimethoprim-sulfamethoxazol prophylaxis on early urinary tract infection after renal transplantation.
dc.typearticle
dc.citation.volume38
dc.citation.issue7
dc.citation.spage2062
dc.citation.epage4
dc.citation.indexPubmed
dc.identifier.DOIhttps://doi.org/10.1016/j.transproceed.2006.06.111


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