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A phase III, randomized, two-armed, double-blind, parallel, active controlled, and non-inferiority clinical trial to compare efficacy and safety of biosimilar adalimumab (CinnoRAآ®) to the reference product (Humiraآ®) in patients with active rheumatoid arthritis
(2017)
Background: This study aimed to compare efficacy and safety of test-adalimumab (CinnoRAآ®, CinnaGen, Iran) to the innovator product (Humiraآ®, AbbVie, USA) in adult patients with active rheumatoid arthritis (RA). Methods: ...
Association between HbA1c levels with severity of coronary artery disease and short-term outcomes of acute ST-elevation myocardial infarction in nondiabetic patients
(2015)
Background: The severity of coronary artery disease (CAD) is directly related to the quality of glucose control in diabetic patients. Additionally, mortality after an acute coronary syndrome is higher in patients with ...
Association of UCP2 -866G>A polymorphism with nonalcoholic fatty liver disease in patients from North-West of Iran
(2017)
Objective: To investigate the association of uncoupling protein-2 (UCP2) -866G>A gene polymorphism (rs659366) with nonalcoholic fatty liver disease (NAFLD). Methods: We performed a case-control study with a cohort of 75 ...
Association of cystathionine beta-synthase polymorphisms and aneurysmal subarachnoid hemorrhage
(2018)
OBJECTIVE Cystathionine b-synthase (CBS) is involved in homocysteine and hydrogen sulfide (H2S) metabolism. Both products have been implicated in the pathophysiology of cerebrovascular diseases. The impact of CBS polymorphisms ...
Association of P53 (?16ins-Pro) Haplotype with the Decreased Risk of Differentiated Thyroid Carcinoma in Iranian-Azeri Patients
(2015)
Association of P53 polymorphisms with the increased risk of various cancers has been investigated in numerous studies. However, the results were conflicting and no polymorphism has been determined as a definite risk factor. ...
Association of high sensitive CRP level and COPD assessment test scores with clinically important predictive outcomes in stable COPD patients
(2015)
Background: High sensitive CRP (hs-CRP) is used as a marker of systemic inflammation in chronic obstructive pulmonary disease (COPD). However, we hypothesize that the raised hs-CRP is not closely related to the multiple ...
Association of CCND1 Gene c.870G>A Polymorphism with Breast Cancer Risk: A Case-ControlStudy and a Meta-Analysis
(2017)
Cyclin D1 (CCND1) plays an essential role in regulating the progress of the cell cycle from G1 to S phase. There is a common c.870G>A polymorphism in the CCND1 gene. The aim of this study was to investigate the association ...
A survey on mental health status of adult population aged 15 and above in the province of East Azarbaijan, Iran
(2017)
Introduction: The main objective of this study was to determine the mental health status of population aged 15 and over in the province of East Azarbaijan in 2015. Methods: The statistical population of this cross-sectional ...
Association between serum kalirin levels and the KALRN gene rs9289231 polymorphism in early-onset coronary artery diseas
(2018)
Background: Recently, rs9289231 genetic variations of kalirin (KALRN) have been introduced as potential genetic markers for coronary artery disease (CAD). However, the influence of KALRN single-nucleotide polymorphisms ...
Associations of pentraxin 3 with presence and severity of coronary artery disease in type 2 diabetes [Tip 2 diyabet hastalar?nda koroner arter hastal??? varl???n?n ve ?iddetinin pentraxin 3 ile ili?kisi]
(2015)
Objective: Pentraxin 3 (PTX3) and C-reactive protein (CRP) may be associated with development of diabetic vascular complications. In the current study we evaluated the relationship between PTX3 levels and the presence and ...