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A phase III, randomized, two-armed, double-blind, parallel, active controlled, and non-inferiority clinical trial to compare efficacy and safety of biosimilar adalimumab (CinnoRAآ®) to the reference product (Humiraآ®) in patients with active rheumatoid arthritis
(2017)
Background: This study aimed to compare efficacy and safety of test-adalimumab (CinnoRAآ®, CinnaGen, Iran) to the innovator product (Humiraآ®, AbbVie, USA) in adult patients with active rheumatoid arthritis (RA). Methods: ...
A Randomized, double-blinded, controlled trial comparing parenteral dextrose 5%, Ringer's solution and oral intake on the delivery outcomes in Nulliparas
(2017)
Objectives: According to the World Health Organization (WHO) statistics, the prevalence of C-section and unnecessary labor induction associated with adverse complications for the mother and baby is rising. This rate is ...
Adherence to Mediterranean nutrition pattern in patients with non-alcoholic fatty liver disease: Relationship with metabolic risk factors and -UCP2-866G/A gene polymorphisms
(2016)
The current study evaluated the association between major components of Mediterranean dietary regimen with metabolic biomarkers and uncoupling protein-2 (UCP2)-866G/A gene polymorphism in patients with non-alcoholic fatty ...
Association of UCP2 -866G>A polymorphism with nonalcoholic fatty liver disease in patients from North-West of Iran
(2017)
Objective: To investigate the association of uncoupling protein-2 (UCP2) -866G>A gene polymorphism (rs659366) with nonalcoholic fatty liver disease (NAFLD). Methods: We performed a case-control study with a cohort of 75 ...
Association of S100B serum levels with metabolic syndrome and its components [Associaç?o dos n?veis de soro S100B com a s?ndrome metab?lica e seus componentes]
(2018)
Introduction: We aimed to compare serum levels of S100B between patients with metabolic syndrome and healthy subjects and to investigate the association of S100B with components of the metabolic syndrome. Materials and ...
Association study of CTLA-4 +49A/G gene polymorphism with recurrent pregnancy loss in the Iranian Azeri Turkish ethnic group
(2017)
Background/aim: Recurrent pregnancy loss (RPL) is defined as two or more pregnancy losses. T-regulatory cells play an important role in the feto-maternal interface. Cytotoxic-T-lymphocyte antigen-4 (CTLA-4) is a molecule ...
Association of endothelial nitric oxide synthase gene variants (-786 T>C, intron 4 b/a VNTR and 894 G>T) with idiopathic recurrent pregnancy loss: A case-control study with haplotype and in silico analysis
(2017)
Objective(s) Many lines of evidence suggest that reduced production of nitric oxide (NO) due to single nucleotide polymorphisms in endothelial nitric oxide synthase (eNOS) gene may affect the implantation and maintenance ...
Association of P53 (?16ins-Pro) Haplotype with the Decreased Risk of Differentiated Thyroid Carcinoma in Iranian-Azeri Patients
(2015)
Association of P53 polymorphisms with the increased risk of various cancers has been investigated in numerous studies. However, the results were conflicting and no polymorphism has been determined as a definite risk factor. ...
Association of high sensitive CRP level and COPD assessment test scores with clinically important predictive outcomes in stable COPD patients
(2015)
Background: High sensitive CRP (hs-CRP) is used as a marker of systemic inflammation in chronic obstructive pulmonary disease (COPD). However, we hypothesize that the raised hs-CRP is not closely related to the multiple ...
Association of MMP-9 promoter polymorphism and breast cancer among Iranian patients
(2017)
Background and aims: Breast cancer is one of the most common cancers in women population. This cancer is influenced by environmental and genetic factors. MMP-9, a member of MMPs family, is located on 20 q11.2- q13.1 and ...