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Cloning and molecular characterization of the cDNAs encoding the variable regions of an anti-CD20 monoclonal antibody
(2017)
BACKGROUND: CD20-based targeting of B-cells in hematologic malignancies and autoimmune disorders is associated with outstanding clinical outcomes. Isolation and characterization of VH and VL cDNAs encoding the variable ...
Production of anti-CD14 monoclonal antibody using synthetic peptide of human CD14 as immunizing antigen.
(2013)
CD14 is a myeloid differentiation antigen expressed primarily on peripheral blood monocytes, dendritic cells and macrophages. It is a key regulator of inflammatory responses to gram-negative bacteria, oxidative burst and ...
Dichloromethane fractions of Scrophularia oxysepala extract induce apoptosis in MCF-7 human breast cancer cells.
(2015)
Breast cancer is a prevalent malignancy among women, especially in developing countries. A large number of anticancer agents with herbal origins have been reported. Hence, herbals may play an essential role in prevention ...
Secretases-related miRNAs in Alzheimer's disease: new approach for biomarker discovery
(2017)
Amyloid-? (A?) as a crucial factor in pathogenesis of Alzheimer's disease (AD) is derived from amyloid precursor protein (APP) through a proteolytic process catalyzing by ?- and ?-secretaseâ€"in amyloidogenesis pathway. ...
IL-4 induces the formation of multinucleated giant cells and expression of ?5 integrin in central giant cell lesion.
(2017)
It is now well established that IL-4 has a central role in the development of monocytes to multinucleated giant cells (MGCs) by inducing the expression of integrins on the surface of monocytes. The aim of this study was ...
BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes
(2016)
Background Metastasis to distant organs is a hallmark of many tumor cells. BACH1 (BTB and CNC homology 1) is a transcriptional factor which promotes the migration and invasion of breast cancer cells. BACH1 expression and ...
Restoration of miR-143 expression could inhibit migration and growth of MDA-MB-468 cells through down-regulating the expression of invasion-related factors.
(2017)
Breast adenocarcinoma is the second common cancer in women the incidence of which is increasing in many countries, especially in developing companies. In this study, miRNA143 has been replaced by vector based microRNA-143 ...
Secretases-related miRNAs in Alzheimer's disease: new approach for biomarker discovery.
(2017)
Amyloid-? (A?) as a crucial factor in pathogenesis of Alzheimer's disease (AD) is derived from amyloid precursor protein (APP) through a proteolytic process catalyzing by ?- and ?-secretase-in amyloidogenesis pathway. ...
Arsenic Trioxide Promotes Paclitaxel Cytotoxicity in Resistant Breast Cancer Cells.
(2015)
A partial response or resistance to chemotherapeutic agents is considered as a main obstacle in treatment of patients with cancer, including breast cancer. Refining taxane-based treatment procedures using adjuvant or ...
TP53 Gene Pro72Arg (rs1042522) Single Nucleotide Polymorphism as Not a Risk Factor for Colorectal Cancer in the Iranian Azari Population
(2017)
Background: The p53 protein participates critically in several cellular functions such as cell growth and DNA
repair. Polymorphisms in the TP53 locus have repeatedly been implicated in the pathogenesis of cancers all over ...