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A unique report: Development of super anti-human IgG monoclone with optical density over than 3
(2013)
Purpose: Monoclonal antibodies and related conjugates are key reagents used in biomedical researches as well as, in treatment, purification and diagnosis of infectious and non- infectious diseases. Methods: Balb/c mice ...
Association of expanded disability status scale and cytokines after intervention with co-supplemented hemp seed, evening primrose oils and hot-natured diet in multiple sclerosis patients
(2013)
Introduction: Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). Because of limited efficacy and adverse side effects, identifying novel therapeutic and protective agents ...
Affinity purification of tumor necrosis factor-? expressed in raji cells by produced scFv antibody coupled CNBr-activated sepharose
(2013)
Purpose: Recombinant tumor necrosis factor-alpha (TNF-?) has been utilized as an antineoplastic agent for the treatment of patients with melanoma and sarcoma. It targets tumor cell antigens by impressing tumor-associated ...
Anti-phospholipase A2 receptor antibody in idiopathic membranous nephropathy: A report from Iranian population
(2013)
Background: Idiopathic Membranous Nephropathy (iMN) is the most common cause of nephrotic syndrome in adults. Approximately one third of patients with iMN progress to end-stage renal disease. Anti-phospholipase A2-receptor ...
BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes
(2016)
Background Metastasis to distant organs is a hallmark of many tumor cells. BACH1 (BTB and CNC homology 1) is a transcriptional factor which promotes the migration and invasion of breast cancer cells. BACH1 expression and ...
Restoration of miR-152 expression suppresses cell proliferation, survival, and migration through inhibition of AKT-ERK pathway in colorectal cancer.
(2018)
MiR-152 has been reported as a tumor suppressor microRNA that is downregulated in a number of cancers, including colorectal cancer (CRC). A recent study suggested that miR-152 could be one of the key regulators of CRC. The ...
DJ1 and microRNA-214 act synergistically to rescue myoblast cells after ischemia/reperfusion injury.
(2018)
Ischemia/reperfusion injury is a tissue injury occurring post-reperfusion of tissues with pre-existing ischemia. A good blood supply to tissues aids in the survival of ischemic tissue, however, due to prolonged ischemia ...
Gene silencing strategies in cancer therapy: An update for drug resistance.
(2018)
RNAi, post-transcriptional gene silencing mechanism, could be considered as one of the most important breakthroughs and rapidly growing fields in science. Researchers are trying to use this discovery in the treatment of ...
TP53 Gene Pro72Arg (rs1042522) Single Nucleotide Polymorphism as Not a Risk Factor for Colorectal Cancer in the Iranian Azari Population
(2017)
Background: The p53 protein participates critically in several cellular functions such as cell growth and DNA
repair. Polymorphisms in the TP53 locus have repeatedly been implicated in the pathogenesis of cancers all over ...