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Secretases-related miRNAs in Alzheimer's disease: new approach for biomarker discovery
(2017)
Amyloid-? (A?) as a crucial factor in pathogenesis of Alzheimer's disease (AD) is derived from amyloid precursor protein (APP) through a proteolytic process catalyzing by ?- and ?-secretaseâ€"in amyloidogenesis pathway. ...
Production and characterization of monoclonal antibodies against human IgG in Balb/c mouse
(2005)
Immunoglobulin G (IgG) is the main immunoglobulin in natural human serum. It constitutes 70 to 75 percent of all immunoglobulins. Monoclonal antibodies have many applications in diagnosis, treatment and purification. The ...
Target therapy of cancer: Implementation of monoclonal antibodies and nanobodies
(2009)
In the past decades, the mainstay of systemic therapy for solid and haematological malignancies was chemotherapy; nevertheless this modality has the drawbacks such as drug resistance and eliciting sever cytotoxicity in the ...
Time - and concentration - dependent effects of resveratrol on miR 15a and miR16-1 expression and apoptosis CCRF-CEM acute lymphoblastic leukemia cell line
(2015)
Background: Chemotherapy is one of the common approaches in treatment of cancers, especially leukemia. However, drug resistance phenomena reduce the likelihood of treatment success. Resveratrol is a herbal compound which ...