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An analysis of suppressing migratory effect on human urinary bladder cancer cell line by silencing of snail-1.
(2017)
Snail-1 actively participates in tumor progression, invasion, and migration. Targeting snail-1 expression can suppress the EMT process in cancer. The aim of this study was to investigate the effect of snail1 silencing on ...
MicroRNAs as novel biomarkers for colorectal cancer: New outlooks.
(2018)
Colorectal cancer is one of the most prevalent cancers with high mortality in the world. MicroRNAs are a class of small non-coding RNAs that regulate gene expression through targeting mRNAs. MicroRNAs involve in many ...
The paradox of Th17 cell functions in tumor immunity.
(2017)
Immune system acts as a host defensive mechanism protecting against attacking pathogens and transformed cells, including cancer cells. Th17 cells are a specific subset of T helper lymphocytes determined by high secretion ...
Immunomodulatory and therapeutic effects of Hot-nature diet and co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients.
(2013)
Multiple sclerosis (MS) is the most chronic and inflammatory disorder. Because of limited efficacy and adverse side effects, identifying novel therapeutic and protective agents is important. This study was aimed to assess ...
MiR-146a functions as a small silent player in gastric cancer.
(2017)
Gastric cancer is responsible for approximately one million annual deaths worldwide. Recently, the important roles of miRNAs as vital factors in malignancy processes such as metastasis have identified. They involve in the ...
The role of CIP2A in cancer: A review and update.
(2017)
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a characterized human oncoprotein that is able to promote cancer cells proliferation, anchorage-independent cell growth and resistance to apoptosis. CIP2A inactivates ...
Double sword role of EZH2 in leukemia.
(2018)
Enhancer of zeste homolog 2 (EZH2), the core component of the polycomb group complex, plays a major role in normal hematopoiesis. The molecular function of EZH2 is to establish H3K27me3 mark on specific genes by which ...
Arsenic Trioxide Promotes Paclitaxel Cytotoxicity in Resistant Breast Cancer Cells.
(2015)
A partial response or resistance to chemotherapeutic agents is considered as a main obstacle in treatment of patients with cancer, including breast cancer. Refining taxane-based treatment procedures using adjuvant or ...
What role can bispecific antibodies play in cancer targeting? A hypothesis.
(2013)
Monoclonal antibodies (mAbs) are currently among the best remedies in the treatment of cancer disorders. Almost 12 anti-cancer therapeutic mAbs have been approved for clinical applications. Although mAbs have been found ...
Regulatory roles of micro-RNAs in T cell autoimmunity.
(2017)
MicroRNAs (miRNAs) are short conserved non-coding RNA molecules that have recently emerged as post-transcriptional gene expression regulators. miRNAs degrade or repress target mRNAs by targeting the 3' UTR region. ...