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Ketoconazole ionic liquids with citric and tartaric acid: Synthesis, characterization and solubility study
(2016)
Solid forms of drugs have some potential problems such as low solubility, slow dissolution rate, variable bioavailability and polymorphism. One of the strategies to overcome these problems is the preparation of ionic liquid ...
Enhancing dissolution, serum concentrations and hypoglycemic effect of glibenclamide using solvent deposition technique
(2005)
Purpose: Glibenclamide is practically insoluble in water and its GI absorption is limited by its dissolution rate. Therefore, to enhance the drug dissolution, serum concentrations and its hypoglycemic effects, it was ...
Assessment of feasibility of maillard reaction between baclofen and lactose by liquid chromatography and tandem mass spectrometry, application to pre formulation studies.
(2009)
The aim of this study was to determine any possible, baclofen-lactose Maillard reaction products. Granules and tablets of baclofen and lactose were prepared and maintained in heat ovens for a certain time period. The effects ...
Design and Optimization of Sustained-Release Divalproex Sodium Tablets with Response Surface Methodology
(2013)
Response surface methodology is defined as a collection of mathematical and statistical methods that are used to develop, improve, or optimize a product or process. In the present study, a statistical design (Mixture Design) ...
Comparative Study of Different Combinational Mucoadhesive Formulations of Sumatriptan-Metoclopramide.
(2016)
Sumatriptan succinate (Sum) is a Serotonin 5- HT1 receptor agonist, used in the treatment of migraine. It is absorbed rapidly but incompletely when taken orally and underwent first - pass metabolism, resulting in a low ...
The Effects of Cetirizine on P-glycoprotein Expression and Function In vitro and In situ.
(2016)
P-glycoprotein (P-gp) plays a major role in oral absorption of drugs. Induction or inhibition of P-gp by drugs contributes to variability of its transport activity and often results in clinically relevant drug-drug ...
Novel Pentablock Copolymers as Thermosensitive Self-Assembling Micelles for Ocular Drug Delivery
(2017)
Many studies have focused on how drugs are formulated in the sol state at room temperature leading to the formation of in situ gel at eye temperature to provide a controlled drug release. Stimuli-responsive block copolymer ...
Thermal Stability and Kinetic Study of Fluvoxamine Stability in Binary Samples with Lactose
(2017)
Purpose: In the present study the incompatibility of FLM (fluvoxamine) with lactose in solid state mixtures was investigated. The compatibility was evaluated using different physicochemical methods such as differential ...
Synthesis, characterization and in vitro anti-tumoral evaluation of Erlotinib-PCEC nanoparticles.
(2014)
Development of a nanosized polymeric delivery system for erlotinib was the main objective of this research.Poly caprolactone-polyethylene glycol-polycaprolactone (PCEC) copolymers with different compositions were synthesized ...
Bioactive constituents from roots of Salvia syriaca L.: Acetylcholinesterase inhibitory activity and molecular docking studies
(2016)
Several Salvia species have been used to enhance memory in European traditional medicine. Accordingly, we aimed to evaluate the acetone extract of the roots of Salvia syriaca for anti-Alzheimer constituents. Structures of ...