جستجو
در حال نمایش آیتم21-30 از 198
A new simulated plasma for assessing the solubility of mineral trioxide aggregate.
(2015)
Solubility of mineral trioxide aggregate (MTA) is an important characteristic that affects other properties such as microleakage and biocompatibility. Distilled water (DW) has previously been used for solubility tests. ...
Design of vancomycin RS-100 nanoparticles in order to increase the intestinal permeability
(2012)
Purpose:The purpose of this work was to preparation of vancomycin (VCM) biodegradable nanoparticles to improve the intestinal permeability, using water-in-oil-in-water (W/O/W) multiple emulsion method. Methods:The ...
Design, synthesis, ?-glucosidase inhibitory activity, molecular docking and QSAR studies of benzimidazole derivatives
(2016)
In this study the green, one-pot, solvent-free and selective synthesis of benzimidazole derivatives is reported. The reactions were catalyzed by ZnO/MgO containing ZnO nanoparticles as a highly effective, non-toxic and ...
Pharmacokinetics and bioequivalence evaluation of two brands of ciprofloxacin 500?mg tablets in Iranian healthy volunteers.
(2012)
In the present study pharmacokinetics and bioequivalence of 2 brands of ciprofloxacin 500?mg were evaluated in 24 healthy male volunteers after a single dose oral administration in an open, randomized, 2-way crossover ...
Preparation of chitosan-plasmid DNA nanoparticles encoding interleukin-12 and their expression in CT-26 colon carcinoma cells.
(2011)
Interleukin-12 (Il-12) as a cytokine has been proved to possess antitumor effects via stimulating the immune system. Non-viral gene delivery systems exhibit low toxicity and are easier to prepare compared to their viral ...
Reduced ABCB1 Expression and Activity in the Presence of Acrylic Copolymers.
(2014)
P-glycoprotein (P-gp; ABCB1), an integral membrane protein in the apical surface of human intestinal epithelial cells, plays a crucial role in the intestinal transport and efflux leading to changes in the bioavailability ...
Development and characterization of solid dispersion of piroxicam for improvement of dissolution rate using hydrophilic carriers
(2014)
Introduction: The main objective of this study was preparation and characterization of solid dispersion of piroxicam to enhance its dissolution rate. Methods: Solid dispersion formulations with different carriers including ...
Development and characterization of solid dispersion for dissolution improvement of furosemide by cogrinding method
(2014)
Purpose: The purpose of this study was to prepare and characterize solid dispersion formulation of furosemide to enhance dissolution rate. Methods: Solid dispersions with different drug: carrier ratios were prepared by ...
Antibacterial activity of clarithromycin loaded PLGA nanoparticles.
(2012)
Novel drug delivery systems such as nanoparticles (NPs) have been proved to enhance the effectiveness of many drugs. Clarithromycin is a broad spectrum macrolide antibiotic, used in many infectious conditions like upper ...
Reciprocal powered time model for release kinetic analysis of ibuprofen solid dispersions in oleaster powder, microcrystalline cellulose and crospovidone.
(2010)
A physically sound derivation for reciprocal power time (RPT) model for kinetic of drug release is given. In order to enhance ibuprofen dissolution, its solid dispersions (SDs) prepared by cogrinding technique using ...