Now showing items 1-10 of 21
Association between MTHFR polymorphism (C677T) with nonfamilial colorectal cancer
The enzyme 5,10-methylene-tetrahydrofolate reductase (MTHFR) is linked to DNA methylation, synthesis, and repair. C677T is one of the most important polymorphisms in the MTHFR gene. The single nucleotide polymorphism C677T ...
Appendectomy, tonsillectomy, and risk of inflammatory bowel disease: A case control study in Iran
There is some controversy about the prevalence of appendectomy and tonsillectomy among patients with Crohn's disease and a lower rate of appendectomy among patients with ulcerative colitis (UC). The objective of this study ...
Association between the 1793G>A MTHFR polymorphism and sporadic colorectal cancer in Iran
Background: It has been proposed that folate and polymorphisms of the enzyme methylenetetrahydrofolate reductase (MTHFR), which regulates influx of folate for methylation reactions for DNA synthesis and repair, are involved ...
Age-specific seroprevalence of hepatitis A infection among children visited in pediatric hospitals of Tehran, Iran
Background: Hepatitis A is an enterically transmitted disease that still remains endemic in many developing countries. In some countries improvements in living conditions have recently led to changing in epidemiology of ...
Evaluation of global genome methylation in gastritis lesion and its correlation with clinicopatological findings
Global genome hypomethylation as an epigenetic phenomenon may induce (pre)neoplastic transformation through inducing chromosomal and genomic instability and activating oncogenes. Global genome hypomethylation has a fundamental ...
FBXW7/hCDC4 is a general tumor suppressor in human cancer
The ubiquitin-proteasome system is a major regulatory pathway of protein degradation and plays an important role in cellular division. Fbxw7 (or hCdc4), a member of the F-box family of proteins, which are substrate recognition ...
Four novel germline mutations in the MLH1 and PMS2 mismatch repair genes in patients with hereditary nonpolyposis colorectal cancer
Background: Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common cause of early onset hereditary colorectal cancer. In the majority of HNPCC families, microsatellite instability (MSI) and germline mutation ...
Gastro-oesophageal reflux disease and irritable bowel syndrome: A significant association in an Iranian population
Background: Gastro-oesophageal reflux disease and irritable bowel syndrome are common diseases, which may be related. Aim: To assess the association between gastro-oesophageal reflux disease and irritable bowel syndrome ...
Glutathione-S-transferase M1, T1 and P1 gene polymorphisms in type I autoimmune hepatitis: A case-control study 
[No abstract available]
Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: A phase I-II clinical trial
BACKGROUND: End-stage liver disease is a medical problem with high morbidity and mortality. We have investigated the feasibility, safety, and efficacy of using autologous mesenchymal stem cells (MSCs) as a treatment. ...