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Mucins in neoplastic spectrum of colorectal polyps: Can they provide predictions?
Background: The significance of expression of different mucins in succession of malignant transformation of colorectal polyps is not determined yet. The aim of the present study was to determine the pattern of expression ...
Profile and frequency of p53 Gene alterations in gastritis lesions from Iran
Background: It has been frequently shown that p53 alterations have an important role in the development of gastric cancers but there is no data on p53 alteration in gastric cancer and its precancerous lesions from Iran ...
Sporadic colorectal polyps and mismatch repair proteins
Background: Colorectal cancers often arise from benign polyps. Adenomatous polyps and serrated polyps progress step by step to adenocarcinoma and change into malignant cancers. Genetic and epigenetic changes have correlation ...
Telomere shortening: A biological marker of sporadic colorectal cancer with normal expression of p53 and mismatch repair proteins
Uncontrolled growth of cells, a main criterion of cancer, is merged with pathologic telomere length alteration. Thereby, measurement of telomere length could provide important information on cell proliferation and senescence ...
Novel missense mutation at codon 2774 (C.8321 G>A) p.S2774n of APC gene in a denovo case of familial adenomatous polyposis
Familial adenomatous polyposis (FAP) is an autosomal dominant inherited disease caused by germline mutation in Adenomatous Polyposis Coli (APC) gene. FAP accounts less than 1% of all colorectal cancers incidence. Patients ...