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Association of cystathionine beta-synthase polymorphisms and aneurysmal subarachnoid hemorrhage

Hendrix, P; Foreman, PM; Harrigan, MR; Fisher, WS; Vyas, NA; Lipsky, RH; Lin, M; Walters, BC; Tubbs, RS; Shoja, MM; Pittet, J-F; Mathru, M; Griessenauer, CJ (2018)

OBJECTIVE Cystathionine b-synthase (CBS) is involved in homocysteine and hydrogen sulfide (H2S) metabolism. Both products have been implicated in the pathophysiology of cerebrovascular diseases. The impact of CBS polymorphisms ...

The role of endothelial nitric oxide synthase -786 T/C polymorphism in cardiac instability following aneurysmal subarachnoid hemorrhage

Hendrix, P; Foreman, PM; Harrigan, MR; Fisher, WS; Vyas, NA; Lipsky, RH; Lin, M; Walters, BC; Tubbs, RS; Shoja, MM; Pittet, J-F; Mathru, M; Griessenauer, CJ (2017)

INTRODUCTION: Cardiac abnormalities are observed frequently after aneurysmal subarachnoid hemorrhage (aSAH). A subset of aSAH patients develops neurogenic cardiomyopathy, likely induced by catecholamine excess. Genetic ...