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Overcoming the Challenges of siRNA Delivery: Nanoparticle Strategies.
(2017)
Despite therapeutics based on siRNA have an immense potential for the treatment of incurable diseases such as cancers. However, the in vivo utilization of siRNA and also the delivery of this agent to the target site is one ...
BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes
(2016)
Background Metastasis to distant organs is a hallmark of many tumor cells. BACH1 (BTB and CNC homology 1) is a transcriptional factor which promotes the migration and invasion of breast cancer cells. BACH1 expression and ...
Restoration of miR-143 expression could inhibit migration and growth of MDA-MB-468 cells through down-regulating the expression of invasion-related factors.
(2017)
Breast adenocarcinoma is the second common cancer in women the incidence of which is increasing in many countries, especially in developing companies. In this study, miRNA143 has been replaced by vector based microRNA-143 ...
Urtica dioica extract suppresses miR-21 and metastasis-related genes in breast cancer.
(2017)
Breast cancer has a high prevalence among women worldwide. Tumor invasion and metastasis still remains an open issue that causes most of the therapeutic failures and remains the prime cause of patient mortality. Hence, ...
Tumor suppressor p53 induces apoptosis of host lymphocytes experimentally infected by Leishmania major, by activation of Bax and caspase-3: a possible survival mechanism for the parasite.
(2017)
Apoptosis of infected host macrophages by Leishmania spp. is mainly addressed as one of the survival mechanisms of the parasite. However, there is no eligible data about whether tumor suppressor p53 could induce the apoptosis ...
An analysis of suppressing migratory effect on human urinary bladder cancer cell line by silencing of snail-1.
(2017)
Snail-1 actively participates in tumor progression, invasion, and migration. Targeting snail-1 expression can suppress the EMT process in cancer. The aim of this study was to investigate the effect of snail1 silencing on ...
MicroRNAs as novel biomarkers for colorectal cancer: New outlooks.
(2018)
Colorectal cancer is one of the most prevalent cancers with high mortality in the world. MicroRNAs are a class of small non-coding RNAs that regulate gene expression through targeting mRNAs. MicroRNAs involve in many ...
MiR-146a functions as a small silent player in gastric cancer.
(2017)
Gastric cancer is responsible for approximately one million annual deaths worldwide. Recently, the important roles of miRNAs as vital factors in malignancy processes such as metastasis have identified. They involve in the ...
Regulatory roles of micro-RNAs in T cell autoimmunity.
(2017)
MicroRNAs (miRNAs) are short conserved non-coding RNA molecules that have recently emerged as post-transcriptional gene expression regulators. miRNAs degrade or repress target mRNAs by targeting the 3' UTR region. ...
MicroRNAs in the Diagnosis and Treatment of Cancer.
(2017)
Immune cells are recruited into the tumor microenvironment and regulate anti- and pro-tumor signals. MicroRNAs (miRNAs) markedly control the immune system responses in cancer development. miRNAs that affect the immune ...