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BACH1 silencing by siRNA inhibits migration of HT-29 colon cancer cells through reduction of metastasis-related genes

Davudian, S; Shajari, N; Kazemi, T; Mansoori, B; Salehi, S; Mohammadi, A; Shanehbandi, D; Shahgoli, VK; Asadi, M; Baradaran, B (2016)

Background Metastasis to distant organs is a hallmark of many tumor cells. BACH1 (BTB and CNC homology 1) is a transcriptional factor which promotes the migration and invasion of breast cancer cells. BACH1 expression and ...

BACH1, the master regulator gene: A novel candidate target for cancer therapy.

Davudian, S; Mansoori, B; Shajari, N; Mohammadi, A; Baradaran, B (2016)

BACH1 (BTB and CNC homology 1, basic leucine zipper transcription factor 1) is a transcriptional factor and a member of cap 'n' collar (CNC) and basic region leucine zipper factor family. In contrast to other bZIP family ...

Urtica dioica dichloromethane extract induce apoptosis from intrinsic pathway on human prostate cancer cells (PC3).

Mohammadi, A; Mansoori, B; Aghapour, M; Baradaran, B (2016)

Prostate cancer is considered as the major cause of death among men around the world. There are a number of medicinal plants triggering apoptosis response in cancer cells, thus have a therapeutic potential. Therefore, ...

Extracts of Scrophularia frigida Boiss display potent antitumor effects in human breast cancer cells by inducing apoptosis and inhibition of expression of the human epidermal growth factor receptor 2.

Goldar, S; Baradaran, B; Shekari Khaniani, M; Azadmehr, A; Derakhshan, SM; Mohammadi, A; Mansoori, B; Khaze, V; Shanehbandi, D; Mohammadnejad, L; Baghbani, E (2016)

Some species of the Scrophularia genus have been extensively used as a natural remedy for treatment of various medical conditions. The objective of this study was to evaluate the growth inhibitory activity of Scrophularia ...

Micro RNA 34a and Let-7a Expression in Human Breast Cancers is Associated with Apoptotic Expression Genes.

Mansoori, B; Mohammadi, A; Shirjang, S; Baghbani, E; Baradaran, B (2016)

Breast cancer is the most common cause of cancer-related death among women in the whole world. MiR- 34a and let-7a are well known tumor suppressors that participate in the regulation of apoptosis, invasion and other cellular ...

The role of microRNAs in colorectal cancer.

Mohammadi, A; Mansoori, B; Baradaran, B (2016)

Colorectal cancer (CRC) is still the third most common cancer in the world. Mechanism of CRC tumorigenesis has been widely studied at the molecular levels, and has been recently entered the area of microRNAs. MicroRNAs are ...

Overcoming the Challenges of siRNA Delivery: Nanoparticle Strategies.

Shajari, N; Mansoori, B; Davudian, S; Mohammadi, A; Baradaran, B (2017)

Despite therapeutics based on siRNA have an immense potential for the treatment of incurable diseases such as cancers. However, the in vivo utilization of siRNA and also the delivery of this agent to the target site is one ...

Mechanisms of immune system activation in mammalians by small interfering RNA (siRNA).

Mansoori, B; Mohammadi, A; Shir Jang, S; Baradaran, B (2016)

RNA interference (RNAi) guided by small interfering RNAs (siRNA), because of its potential to target and silence the expression of specific genes is utilized as an effective tool in a variety of biological applications. ...

The Urtica dioica extract enhances sensitivity of paclitaxel drug to MDA-MB-468 breast cancer cells.

Mohammadi, A; Mansoori, B; Aghapour, M; Shirjang, S; Nami, S; Baradaran, B (2016)

Due to the chemo resistant nature of cancer cells and adverse effects of current therapies, researchers are looking for the most efficient therapeutic approach which has the lowest side effects and the highest toxicity on ...

siRNA-Mediated Silencing of HMGA2 Induces Apoptosis and Cell Cycle Arrest in Human Colorectal Carcinoma.

Esmailzadeh, S; Mansoori, B; Mohammadi, A; Shanehbandi, D; Baradaran, B (2017)

Overexpression of HMGA2, known as small non-histone chromosomal protein, is associated with progression of various tumors, including colorectal cancers. The aim of this study was to investigate the effect of a specific ...