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Cloning and molecular characterization of the cDNAs encoding the variable regions of an anti-CD20 monoclonal antibody
(2017)
BACKGROUND: CD20-based targeting of B-cells in hematologic malignancies and autoimmune disorders is associated with outstanding clinical outcomes. Isolation and characterization of VH and VL cDNAs encoding the variable ...
Isolation and characterization of anti ROR1 single chain fragment variable antibodies using phage display technique
(2017)
Receptor tyrosine kinase-like orphan receptor (ROR1) belongs to one of the families of receptor tyrosine kinases (RTKs). RTKs are involved in the various physiologic cellular functions including proliferation, migration, ...
Production and characterization of monoclonal antibodies against human IgG in Balb/c mouse
(2005)
Immunoglobulin G (IgG) is the main immunoglobulin in natural human serum. It constitutes 70 to 75 percent of all immunoglobulins. Monoclonal antibodies have many applications in diagnosis, treatment and purification. The ...
Production of anti-CD14 monoclonal antibody using synthetic peptide of human CD14 as immunizing antigen.
(2013)
CD14 is a myeloid differentiation antigen expressed primarily on peripheral blood monocytes, dendritic cells and macrophages. It is a key regulator of inflammatory responses to gram-negative bacteria, oxidative burst and ...
Echinophora platyloba DC (Apiaceae) crude extract induces apoptosis in human prostate adenocarcinoma cells (PC 3).
Prostate cancer is the second leading malignancy worldwide and the second prominent cause of cancer-related deaths among men. Therefore, there is a serious necessity for finding advanced alternative therapeutic measures ...
Targeted therapy of solid tumors by monoclonal antibody specific to epidermal growth factor receptor.
(2014)
Tumor growth and progression depends largely on the activity of cell membrane receptors like epidermal growth factor receptor (EGFR) that plays a pivotal role in the progression and invasion of different solid tumors. As ...
Development and characterization of monoclonal antibodies against human IgA in Balb/c mice.
(2014)
Immunoglobulin A (IgA) is the second immunoglobulin in human serum. Monoclonal antibodies have many potential uses in diagnosis, treatment and purification. The conjugated monoclonal antibodies against human IgA are utilized ...
Impacts of anti-EGFR monoclonal antibody in prostate cancer PC3 cells.
(2010)
Epidermal growth factor receptor (EGFR) network appears to be a rich target for prostate cancer. Thus, in this current investigation, to pursue our newly developed anti-EGFR monoclonal antibody (mAb) in prostate cancer, ...
An analysis of suppressing migratory effect on human urinary bladder cancer cell line by silencing of snail-1.
(2017)
Snail-1 actively participates in tumor progression, invasion, and migration. Targeting snail-1 expression can suppress the EMT process in cancer. The aim of this study was to investigate the effect of snail1 silencing on ...
Development and characterization of monoclonal antibodies against human CD20 in Balb/c mice
(2012)
BACKGROUND: Targeting CD20 antigen on B-lymphocytes provides good opportunity for management of the target cells in patients with B-cell malignancies. By the advent of hybridoma technology, monoclonal antibodies applications ...