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Investigation of the intestinal permeability of ciclosporin using the in situ technique in rats and the relevance of P-glycoprotein
(2008)
The primary endpoint of this study was to determine the intestinal permeability of ciclosporin (cyclosporine A, CsA, CAS 59865-13-3) using the single-pass intestinal perfusion technique (SPIP) and a range of concentrations ...
Effect of sodium carboxyl methylcellulose on intestinal permeability of furosemide
(2010)
Objectives: The aim of this project was determination of intestinal absorption of furosemide in the presence of anionic macromolecules. Methods: In the present study the SPIP technique was used for permeability determination ...
Enhancing dissolution, serum concentrations and hypoglycemic effect of glibenclamide using solvent deposition technique
(2005)
Purpose: Glibenclamide is practically insoluble in water and its GI absorption is limited by its dissolution rate. Therefore, to enhance the drug dissolution, serum concentrations and its hypoglycemic effects, it was ...
The relation between molecular properties of drugs and their transport across the intestinal membrane
(2006)
The aim of this study was to investigate the relationship between the intestinal absorption of structurally diverse model drugs across the rat intestinal mucosa and their molecular properties. Permeability coefficients for ...
Methods to study the gastrointestinal absorption and permeability of drugs
(2009)
Objectives: There are several approaches to gain early information regarding the intestinal permeability and potential for intestinal absorption of drugs. Thus in the present work, different methods available in scientific ...
Simultaneous determination of metoprolol, propranolol and phenol red in samples from rat in situ intestinal perfusion studies
(2006)
Single-pass intestinal perfusion technique (SPIP) is the most used classic technique employed in the study of intestinal absorption of compounds in which a non-absorbable marker such as phenol red is used to correct the ...
Solid lipid nanoparticles and nanostructured lipid carriers: Structure preparation and application
(2015)
Lipid nanoparticles (LNPs) have attracted special interest during last few decades. Solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are two major types of Lipid-based nanoparticles. SLNs were ...
Effect of erythromycin and clarithromycin on the intestinal transport of digoxin
(2009)
Objectives: The purpose of the study was determining the intestinal permeability of digoxin using the SPIP technique and a range of concentrations in rats and assessing the quantitative contribution of P-gp-mediated efflux ...
Biological activities of Salvia santolinifolia Boiss. A multifunctional medicinal plant
(2016)
Background: Salvia species are used traditionally for treatment of many disorders all around the world. Salvia santolinifolia is a medicinal plant, traditionally used for treatment of inflammation, hypercholesterolemia, ...
Predicting human intestinal permeability using single-pass intestinal perfusion to rat
(2007)
Purpose. The aim of the study was the prediction of human intestinal permeability and fraction absorbed of oral dose using single-pass intestinal perfusion technique (SPIP) in rats. Methods. Permeability coefficients in ...