Search
Now showing items 1-10 of 16
Anti-bacterial performance of azithromycin nanoparticles as colloidal drug delivery system against different gram-negative and gram-positive bacteria
(2012)
Purpose: Azithromycin (AZI) is a new macrolide antibiotic with a better activity against intracellular gram negative bacteria in comparison with Erythromycin. The purpose of this research was to prepare AZI nanoparticles ...
Biological activities of Salvia santolinifolia Boiss. A multifunctional medicinal plant
(2016)
Background: Salvia species are used traditionally for treatment of many disorders all around the world. Salvia santolinifolia is a medicinal plant, traditionally used for treatment of inflammation, hypercholesterolemia, ...
Design of vancomycin RS-100 nanoparticles in order to increase the intestinal permeability
(2012)
Purpose:The purpose of this work was to preparation of vancomycin (VCM) biodegradable nanoparticles to improve the intestinal permeability, using water-in-oil-in-water (W/O/W) multiple emulsion method. Methods:The ...
Effect of erythromycin and clarithromycin on the intestinal transport of digoxin
(2009)
Objectives: The purpose of the study was determining the intestinal permeability of digoxin using the SPIP technique and a range of concentrations in rats and assessing the quantitative contribution of P-gp-mediated efflux ...
Effect of sodium carboxyl methylcellulose on intestinal permeability of furosemide
(2010)
Objectives: The aim of this project was determination of intestinal absorption of furosemide in the presence of anionic macromolecules. Methods: In the present study the SPIP technique was used for permeability determination ...
Enhancing dissolution, serum concentrations and hypoglycemic effect of glibenclamide using solvent deposition technique
(2005)
Purpose: Glibenclamide is practically insoluble in water and its GI absorption is limited by its dissolution rate. Therefore, to enhance the drug dissolution, serum concentrations and its hypoglycemic effects, it was ...
Formulation and physicochemical characterization of buccoadhesive microspheres containing diclofenac sodium
(2014)
Purpose: The present study involves preparation and evaluation of diclofenac buccal-mucoadhesive microparticles for prolongation of buccal residence time. Methods: The microparticles were prepared by modified double-emulsion ...
Investigation of the intestinal permeability of ciclosporin using the in situ technique in rats and the relevance of P-glycoprotein
(2008)
The primary endpoint of this study was to determine the intestinal permeability of ciclosporin (cyclosporine A, CsA, CAS 59865-13-3) using the single-pass intestinal perfusion technique (SPIP) and a range of concentrations ...
Methods to study the gastrointestinal absorption and permeability of drugs
(2009)
Objectives: There are several approaches to gain early information regarding the intestinal permeability and potential for intestinal absorption of drugs. Thus in the present work, different methods available in scientific ...
Simultaneous determination of metoprolol, propranolol and phenol red in samples from rat in situ intestinal perfusion studies
(2006)
Single-pass intestinal perfusion technique (SPIP) is the most used classic technique employed in the study of intestinal absorption of compounds in which a non-absorbable marker such as phenol red is used to correct the ...