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Anti-bacterial performance of azithromycin nanoparticles as colloidal drug delivery system against different gram-negative and gram-positive bacteria
(2012)
Purpose: Azithromycin (AZI) is a new macrolide antibiotic with a better activity against intracellular gram negative bacteria in comparison with Erythromycin. The purpose of this research was to prepare AZI nanoparticles ...
Application of lactobionic acid and nonionic surfactants as solubilizing agents for parenteral formulation of clarithromycin
(2012)
Purpose: The purpose of this paper is to enhance the solubility of clarithromycin (CLR) using nonionic surfactants and some type of acids for preparation of the new formulations. Methods: Myrj 52 and chremophor (2.5 and ...
Application of response surface methodology in development of sirolimus liposomes prepared by thin film hydration technique
(2013)
The present investigation was aimed to optimize the formulating process of sirolimus liposomes by thin film hydration method. Methods: In this study, a 32 factorial design method was used to investigate the influence of ...
Comparison of the effect of hydrogel and solution forms of sodium ascorbate on orthodontic bracket-enamel shear bond strength immediately after bleaching: An in vitro study
(2010)
Aim: This study compared the effects of hydrogel and solution forms of sodium ascorbate (SA) with two different application times on bracket bond strength subsequent to bleaching. Materials and Methods: A total of 72 sound ...
Design of vancomycin RS-100 nanoparticles in order to increase the intestinal permeability
(2012)
Purpose:The purpose of this work was to preparation of vancomycin (VCM) biodegradable nanoparticles to improve the intestinal permeability, using water-in-oil-in-water (W/O/W) multiple emulsion method. Methods:The ...
Development and characterization of solid dispersion for dissolution improvement of furosemide by cogrinding method
(2014)
Purpose: The purpose of this study was to prepare and characterize solid dispersion formulation of furosemide to enhance dissolution rate. Methods: Solid dispersions with different drug: carrier ratios were prepared by ...
Development and validation of an HPLC method for the analysis of sirolimus in drug products
(2012)
Purpose: The aim of this study was to develop a simple, rapid and sensitive reverse phase high performance liquid chromatography (RP-HPLC) method for quantification of sirolimus (SRL) in pharmaceutical dosage forms. Methods: ...
Development and physicochemical characterization of sirolimus solid dispersions prepared by solvent evaporation method
(2014)
Purpose: The aim of the present investigation was preparation and characterization of sirolimus solid dispersions by solvent evaporation technique to improve its dissolution properties. Methods: Polyvinylpyrrolidone (PVP), ...
Effect of erythromycin and clarithromycin on the intestinal transport of digoxin
(2009)
Objectives: The purpose of the study was determining the intestinal permeability of digoxin using the SPIP technique and a range of concentrations in rats and assessing the quantitative contribution of P-gp-mediated efflux ...
Detection of gabapentin-lactose maillard reaction product (Schiff's base): Application to solid dosage form preformulation / Part 1
(2011)
In the following study several techniques are utilized such as Differential Scanning Calorimetery (DSC), Infra-Red (IR) spectroscopy, High Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass Spectrometry/Mass ...