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Investigation of the intestinal permeability of ciclosporin using the in situ technique in rats and the relevance of P-glycoprotein
(2008)
The primary endpoint of this study was to determine the intestinal permeability of ciclosporin (cyclosporine A, CsA, CAS 59865-13-3) using the single-pass intestinal perfusion technique (SPIP) and a range of concentrations ...
Investigation of digoxin solubility in different cosolvent systems
(2012)
Objectives: Digoxin is a drug with very low aqueous solubility, low therapeutic dose and low therapeutic index. Soft gelatin capsule is an ideal dosage form to formulate low soluble drugs that provides faster dissolution, ...
Rapid IIPLC determination of pioglitazone in human plasma by protein precipitation and its application to pharmacokinetic studies
(2010)
A simple and rapid HPLC method with UV detection was developed for the determination of pioglitazone in human plasma. The method was based on protein precipitation using perchloric acid on an ODS column. The mobile phase ...
Effect of sodium carboxy methylcellulose on dialysis rate of furosemide
(2009)
Objectives: Drug delivery of impermeable drugs through biological membrane is currently one of the major interests in pharmaceutical research. It has been shown that there are different absorption enhancers which can provide ...
Effects of formulation variables and storage conditions on light protected vitamin B12 mixed parenteral formulations
(2014)
Purpose: In this research the effect of vitamin B1 and B6 on cyanocobalamin stability in commercial light protected parenteral formulations and upon adding stabilizing agents will be investigated and best formulation ...
Effect of sodium carboxyl methylcellulose on intestinal permeability of furosemide
(2010)
Objectives: The aim of this project was determination of intestinal absorption of furosemide in the presence of anionic macromolecules. Methods: In the present study the SPIP technique was used for permeability determination ...
Enhancing dissolution, serum concentrations and hypoglycemic effect of glibenclamide using solvent deposition technique
(2005)
Purpose: Glibenclamide is practically insoluble in water and its GI absorption is limited by its dissolution rate. Therefore, to enhance the drug dissolution, serum concentrations and its hypoglycemic effects, it was ...
Single dose bioequivalence study of two brands of olanzapine 10 mg tablets in Iranian healthy volunteers
(2013)
This single dose, randomized, open label, 2-period and crossover study in healthy Iranian adult volunteers was conducted to compare the bioavailability of 2 branded formulations of olanzapine 10 mg tablets. 24 volunteers ...
The relation between molecular properties of drugs and their transport across the intestinal membrane
(2006)
The aim of this study was to investigate the relationship between the intestinal absorption of structurally diverse model drugs across the rat intestinal mucosa and their molecular properties. Permeability coefficients for ...
Single dose bioequivalence study of ?-methyldopa tablet formulations using a modified HPLC method
(2010)
Background and objective: The purpose of the present study was to compare the bioavailability of a new methyldopa (CAS 555-30-6) tablet formulation with that of a reference formulation in 12 healthy male subjects using a ...