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Preparation of chitosan-plasmid DNA nanoparticles encoding interleukin-12 and their expression in CT-26 colon carcinoma cells.
(2011)
Interleukin-12 (Il-12) as a cytokine has been proved to possess antitumor effects via stimulating the immune system. Non-viral gene delivery systems exhibit low toxicity and are easier to prepare compared to their viral ...
Synthesis, characterization and in vitro anti-tumoral evaluation of Erlotinib-PCEC nanoparticles.
(2014)
Development of a nanosized polymeric delivery system for erlotinib was the main objective of this research.Poly caprolactone-polyethylene glycol-polycaprolactone (PCEC) copolymers with different compositions were synthesized ...
Development of azithromycin-PLGA nanoparticles: physicochemical characterization and antibacterial effect against Salmonella typhi.
(2010)
The objective of the present research was to formulate poly(lactide-co-glycolide) nanoparticles loaded with azithromycin with appropriate physicochemical properties and antimicrobial activity. Azithromycin-loaded ...
Preparation of diclofenac sodium composite microparticles with improved initial release property
(2010)
The aim of this study is the evaluation of the effect of microencapsulation of nanoparticles in composite microparticles on the reduction of burst release. Microparticles (simple and composite) and nanoparticles were ...
Development of dry powder inhaler formulation loaded with alendronate solid lipid nanoparticles: solid-state characterization and aerosol dispersion performance.
(2015)
Alendronate sodium is a bisphosphonate drug used for the treatment of osteoporosis and acts as a specific inhibitor of osteoclast-mediated bone resorption. Inhalable solid lipid nanoparticles (SLNs) of the alendronate were ...
Antibacterial activity of clarithromycin loaded PLGA nanoparticles.
(2012)
Novel drug delivery systems such as nanoparticles (NPs) have been proved to enhance the effectiveness of many drugs. Clarithromycin is a broad spectrum macrolide antibiotic, used in many infectious conditions like upper ...
Development of pH-sensitive insulin nanoparticles using Eudragit L100-55 and chitosan with different molecular weights.
(2010)
Insulin is a polypeptide hormone and usually administered for treatment of diabetic patients subcutaneously. The aim of this study was to investigate the efficiency of enteric nanoparticles for oral delivery of insulin. ...
Statistical Optimization of Oral Vancomycin-Eudragit RS Nanoparticles Using Response Surface Methodology
(2012)
A Box-Behnken design with three replicates was used for preparation and evaluation of Eudragit vancomycin (VCM) nanoparticles prepared by double emulsion. The purpose of this work was to optimize VCM nanoparticles to improve ...
The characteristics and improved intestinal permeability of vancomycin PLGA-nanoparticles as colloidal drug delivery system.
(2013)
In the present investigation, vancomycin (VCM) biodegradable nanoparticles were developed for oral administration, with the aim of improving its intestinal permeability.The vancomycin-loaded nanoparticles were prepared ...
Development and Optimisation of Spironolactone Nanoparticles for Enhanced Dissolution Rates and Stability.
(2017)
Stable solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) formulations to enhance the dissolution rates of poorly soluble drug spironolactone (SP) were being developed. Probe ultra-sonication method ...