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Investigation of the intestinal permeability of ciclosporin using the in situ technique in rats and the relevance of P-glycoprotein
(2008)
The primary endpoint of this study was to determine the intestinal permeability of ciclosporin (cyclosporine A, CsA, CAS 59865-13-3) using the single-pass intestinal perfusion technique (SPIP) and a range of concentrations ...
Nasal carriage rate of Staphylococcus aureus among patients with systemic lupus erythematosus and its correlation with disease relapse
(2015)
Introduction: Systemic lupus erythematosus (SLE) is an autoimmune disease with unknown origin. The disease causes a broad spectrum of signs and symptoms in a majority of body organs. Due to several factors like damage to ...
The utility of rat jejunal permeability for biopharmaceutics classification system
(2009)
Purpose: The biopharmaceutical classification system has been developed to provide a scientific approach for classifying drug compounds based on their dose/solubility ratio and human intestinal permeability. Therefore in ...
Application of Artificial Intelligent Tools to Modeling of Glucosamine Preparation from Exoskeleton of Shrimp
(2009)
The objective of this study was to forecast and optimize the glucosamine production yield from chitin (obtained from Persian Gulf shrimp) by means of genetic algorithm (GA), particle swarm optimization (PSO), and artificial ...
Investigation of digoxin solubility in different cosolvent systems
(2012)
Objectives: Digoxin is a drug with very low aqueous solubility, low therapeutic dose and low therapeutic index. Soft gelatin capsule is an ideal dosage form to formulate low soluble drugs that provides faster dissolution, ...
Enhanced cellular internalization of CdTe quantum dots mediated by arginine- and tryptophan-rich cell-penetrating peptides as efficient carriers.
(2016)
Quantum dots (QDs), as a new class of fluorescent tags, have been widely used for biomedical applications. Despite their various advantages, QDs do not efficiently enter cells on their own, and aggregation often occurs ...
Physicochemical analysis and nonisothermal kinetic study of sertraline-elactose binary mixtures
(2017)
In the present study the physicochemical stability of sertraline with lactose was evaluated in drug-excipient binary mixtures. Different physicochemical methods such as differential scanning calorimetry (DSC), Fourier-transform ...
Evaluation of in vitro-in vivo correlation and anticonvulsive effect of carbamazepine after cogrinding with microcrystalline cellulose
(2006)
Purpose. Carbamazepine is a poor water soluble drug and its bioavailability is limited by dissolution rate. Dissolution, serum concentration and anticonvulsive effect of the drug have been evaluated after cogrinding with ...
Rapid IIPLC determination of pioglitazone in human plasma by protein precipitation and its application to pharmacokinetic studies
(2010)
A simple and rapid HPLC method with UV detection was developed for the determination of pioglitazone in human plasma. The method was based on protein precipitation using perchloric acid on an ODS column. The mobile phase ...
Interactions Between Sirolimus and Anti-Inflammatory Drugs: Competitive Binding for Human Serum Albumin.
(2016)
The aim of the present study was investigating the effects of three anti-inflammatory drugs, on Sirolimus protein biding. The binding site of Sirolimus on human serum albumin (HSA) was also determined.Six different ...