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Physicochemical analysis and nonisothermal kinetic study of sertraline-elactose binary mixtures
(2017)
In the present study the physicochemical stability of sertraline with lactose was evaluated in drug-excipient binary mixtures. Different physicochemical methods such as differential scanning calorimetry (DSC), Fourier-transform ...
Effects of formulation variables and storage conditions on light protected vitamin B12 mixed parenteral formulations
(2014)
Purpose: In this research the effect of vitamin B1 and B6 on cyanocobalamin stability in commercial light protected parenteral formulations and upon adding stabilizing agents will be investigated and best formulation ...
Assessment of feasibility of maillard reaction between baclofen and lactose by liquid chromatography and tandem mass spectrometry, application to pre formulation studies.
(2009)
The aim of this study was to determine any possible, baclofen-lactose Maillard reaction products. Granules and tablets of baclofen and lactose were prepared and maintained in heat ovens for a certain time period. The effects ...
Design and Optimization of Sustained-Release Divalproex Sodium Tablets with Response Surface Methodology
(2013)
Response surface methodology is defined as a collection of mathematical and statistical methods that are used to develop, improve, or optimize a product or process. In the present study, a statistical design (Mixture Design) ...
Thermal Stability and Kinetic Study of Fluvoxamine Stability in Binary Samples with Lactose
(2017)
Purpose: In the present study the incompatibility of FLM (fluvoxamine) with lactose in solid state mixtures was investigated. The compatibility was evaluated using different physicochemical methods such as differential ...
Detection of Gabapentin-Lactose Maillard Reaction Product (Schiff's Base) Application to solid dosage form preformulation/Part 1
(2011)
In the following study several techniques are utilized such as Differential Scanning Calorimetery (DSC), Infra-Red (IR) spectroscopy, High Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass Spectrometry/Mass ...
Kinetics study of hydrochlorothiazide lactose liquid state interaction using conventional isothermal arrhenius method under basic and neutral conditions
(2016)
The Maillard reaction of hydrochlorothiazide (HCTZ) and lactose has been previously demonstrated in pharmaceutical formulations. In this study, the activation energy of - hydrohlorothiazide and lactose interaction in the ...
Evaluation of activation energy conformity derived from model-free non-isothermal predictions and Arrhenius isothermal results: The case of hydrochlorothiazide-lactose reaction
(2017)
In this study, the activation energy of HCTZ-lactose interaction was determined and compared to isothermal and non-isothermal methods. DSC data were fitted to different thermal models such as Friedman, Flynn-Wall-Ozawa and ...