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Mass-production and characterization of anti-CD20 monoclonal antibody in peritoneum of Balb/c mice
(2013)
Purpose: Monoclonal antibodies are important tools are used in basic research as well as, in diagnosis, imaging and treatment of immunodeficiency diseases, infections and cancers. The purpose of this study was to produce ...
Large scale generation and characterization of anti-human CD34 monoclonal antibody in ascetic fluid of balb/c mice
(2013)
Purpose: Monoclonal antibodies or specific antibodies are now an essential tool of biomedical research and are of great commercial and medical value. The purpose of this study was to produce large scale of monoclonal ...
Inhibition of growth and induction of apoptosis in fibrosarcoma cell lines by echinophora platyloba DC: In vitro analysis
(2013)
Echinophora platyloba DC plant (Khousharizeh) is one of the indigenous medicinal plants which is used as a food seasoning and medicine in Iran. The objective of this study was to examine the in vitro cytotoxic activity and ...
Cloning and expression of the variable regions of anti-EGFR monoclonal antibody in E. coli for production of a single chain antibody
(2014)
Background: Epidermal growth factor receptor (EGFR) overexpression is a characteristic of several malignancies and could be considered as an excellent target for designing specific inhibitors such as anti-EGFR monoclonal ...
Production and characterization of monoclonal antibodies against human IgG in Balb/c mouse
(2005)
Immunoglobulin G (IgG) is the main immunoglobulin in natural human serum. It constitutes 70 to 75 percent of all immunoglobulins. Monoclonal antibodies have many applications in diagnosis, treatment and purification. The ...
TLR-2, IL-10 and IL-17-mediated immunity in experimental chemotherapy murine model of systemic candidiasis; cyclophosphamides' impact and roles
(2018)
The majority of immune components such as Toll-like receptor (TLR)-2, interleukin (IL)-17, neutrophils, and IL-10 play pivotal roles in immunity to Candida albicans (C. albicans) through identifying and launching inflammatory ...
Inhibition of mitochondrial permeability transition pore restores the cardioprotection by postconditioning in diabetic hearts
(2014)
Background: Cardiovascular risk factors, including diabetes mellitus may attenuate the cardioprotection by postconditioning. This study aimed to investigate the cardioprotective effect of ischemic-postconditioning (IPostC) ...
Effect of long-term dietary restriction on myocardial apoptosis
(2015)
Background: Caloric or dietary restriction (DR) is a practical intervention for weight loss and increasing lifespan. However, the effects of long-term dietary restriction and signaling process of it on cell aging and ...
Secretases-related miRNAs in Alzheimer's disease: new approach for biomarker discovery
(2017)
Amyloid-? (A?) as a crucial factor in pathogenesis of Alzheimer's disease (AD) is derived from amyloid precursor protein (APP) through a proteolytic process catalyzing by ?- and ?-secretaseâ€"in amyloidogenesis pathway. ...
Recombinant expression and purification of Pseudomonas aeruginosa truncated exotoxin A in Escherichia coli
(2013)
Background: Pseudomonas (P.) aeruginosa exotoxin A (PE) is one of the most potent bacterial toxins ever been identified. It catalyzes ADP-ribosylation of cellular elongation factor 2 and specifically arrests protein synthesis ...