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A unique report: Development of super anti-human IgG monoclone with optical density over than 3
(2013)
Purpose: Monoclonal antibodies and related conjugates are key reagents used in biomedical researches as well as, in treatment, purification and diagnosis of infectious and non- infectious diseases. Methods: Balb/c mice ...
Cloning and expression of the variable regions of anti-EGFR monoclonal antibody in E. coli for production of a single chain antibody
(2014)
Background: Epidermal growth factor receptor (EGFR) overexpression is a characteristic of several malignancies and could be considered as an excellent target for designing specific inhibitors such as anti-EGFR monoclonal ...
Cytotoxic effects of alcoholic extract of Dorema Glabrum seed on cancerous cells viability
(2013)
Purpose: In the present study cytotoxic effects of the alcoholic extract of Dorema Glabrum seed on viability of WEHI-164 cells, mouse Fibrosarcoma cell line and L929 normal cells were compared with the cytotoxic effects ...
Cytotoxic and apoptotic effects of Ornithogalum cuspidatum methanolic extract on WEHI-164 fibrosarcoma cancer cell line
(2010)
Objectives: Ornithogalum cuspidatum is one of the medicinal plants that has been used in Iranian traditional medicine as treatment for respiratory and inflammatory diseaes. Previous studies on other Ornithogalum species ...
Downstream characterization of anti-TNF-? single chain variable fragment antibodies
(2012)
Using phage display technology (PDT), we have recently isolated single-chain variable fragment (scFv) antibodies (Ab) against some pivotal molecular markers involved in malignancies and systemic inflammation including human ...
Development and characterization of monoclonal antibodies against human CD20 in Balb/c mice
(2012)
BACKGROUND: Targeting CD20 antigen on B-lymphocytes provides good opportunity for management of the target cells in patients with B-cell malignancies. By the advent of hybridoma technology, monoclonal antibodies applications ...
Development and characterization of monoclonal antibodies against human epidermal growth factor receptor in Balb/c mice
(2009)
For production of monoclonal antibody (mAb) against human epidermal growth factor receptor (EGFR), first, five female Balb/c mice 6 to 8 weeks old were immunized against A431 tumoral cells that express more EGFR on its ...
Evaluation of cytotoxic effect of methanolic extract fractions of Ornithogalum cuspidatum on WEHI-164 fibrosarcoma cancer cell line
(2012)
Objectives: The medicinal plant of Ornithogalum cuspidatum (Liliaceae) uses widely in Iranian traditional medicine for treatment of respiratory and inflammatory disease. Previous study on methanolic extract of Ornithogalum ...
Effect of long-term dietary restriction on myocardial apoptosis
(2015)
Background: Caloric or dietary restriction (DR) is a practical intervention for weight loss and increasing lifespan. However, the effects of long-term dietary restriction and signaling process of it on cell aging and ...
Gene therapy, early promises, subsequent problems, and recent breakthroughs
(2013)
Gene therapy is one of the most attractive fields in medicine. The concept of gene delivery to tissues for clinical applications has been discussed around half a century, but scientist's ability to manipulate genetic ...