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Adipocyte derived hormones gene expression, resistin and visfatin, in AGS gastric cancer cell line
(2013)
Background: Adipose tissue has characteristics of an endocrine organ which releases a number of adipocyte-specific factors, known as adipocytokines. It has recently suggested that adipocytokines might play a role in ...
Association between C-reactive protein and HbA1C among patients with type 2 diabetes mellitus
(2007)
Background: Type 2 diabetes mellitus is a common metabolic disorder witht increasing prevalence is increasing worldwide. C-Reactive Protein (CRP) is a marker of systemic inflammation and an independent risk factor for ...
Association between serum kalirin levels and the KALRN gene rs9289231 polymorphism in early-onset coronary artery diseas
(2018)
Background: Recently, rs9289231 genetic variations of kalirin (KALRN) have been introduced as potential genetic markers for coronary artery disease (CAD). However, the influence of KALRN single-nucleotide polymorphisms ...
Reversion of Multidrug Resistance by Co-Encapsulation of Doxorubicin and Metformin in Poly(lactide-co-glycolide)-d-?-tocopheryl Polyethylene Glycol 1000 Succinate Nanoparticles.
(2018)
P-glycoprotein (P-gp) mediated multidrug resistance (MDR) has been recognized as the main obstacle against successful cancer treatment. To address this problem, co-encapsulated doxorubicin (DOX) and metformin (Met) in a ...
Effects of nano-encapsulated curcumin-chrysin on telomerase, MMPs and TIMPs gene expression in mouse B16F10 melanoma tumour model.
(2018)
Due to the high rate of drug resistance among malignant melanoma cases, it seems necessary to introduce an efficient pharmaceutical approach to melanoma treatment. For this purpose, Curcumin (Cur) and Chrysin (Chr), two ...
Balaglitazone reverses P-glycoprotein-mediated multidrug resistance via upregulation of PTEN in a PPAR?-dependent manner in leukemia cells
(2017)
Multidrug resistance in tumor cells is still a big challenge in cancer treatment. Therefore, identification ofsafe and effective multidrug resistance-reversing compounds with minimal side effects is an important approach ...
Biomimetic synthesis of silver nanoparticles using Matricaria chamomilla extract and their potential anticancer activity against human lung cancer cells
(2018)
Herbs having various natural substances can be utilized for the biosynthesis of Silver nanoparticles (AgNPs) and act as a stable, reliable and biocompatible alternative instead of the current physical and chemical approaches. ...
Co-inhibition of Notch and NF-?B Signaling Pathway Decreases Proliferation through Downregulating I?B-? and Hes-1 Expression in Human Ovarian Cancer OVCAR-3 Cells
(2017)
Background: Ovarian cancer is one of the most lethal gynecological malignancies and numerous changes in signaling cascades are involved in the initiation and progression of ovarian cancerous cells. Here, we investigated ...
Design and Development of Modified mRNA Encoding Core Antigen of Hepatitis C Virus: a Possible Application in Vaccine Production
(2018)
Hepatitis C virus (HCV) is a "ژblood-borne pathogen, resulting in liver cirrhosis and liver cancer. Despite of many efforts in development of treatments for HCV, no vaccine has been licensed yet. The purpose of this study ...