Now showing items 1-10 of 234
Association of KALRN, ADIPOQ, and FTO gene polymorphism in type 2 diabetic patients with coronary artery disease: possible predisposing markers.
Recently, several genes have been introduced as potential genetic markers for diabetes mellitus and coronary artery diseases (CAD).In this case-control study, the associations of rs2241766 T/G of ADIPOQ, rs9289231 T/G of ...
An Update on Phytochemicals in Molecular Target Therapy of Cancer: Potential Inhibitory Effect on Telomerase Activity.
Telomerase is a ribonucleoprotein enzyme, which has a significant role in synthesizing DNA telomeric in eukaryotes. Telomere maintenance can cause to immortalization and malignant transformation of human cells and thereby ...
Polyelectrolyte complexes of hTERT siRNA and polyethyleneimine: Effect of degree of PEG grafting on biological and cellular activity.
Gene silencing by siRNA (short interfering RNA)-targeted human telomerase reverse transcriptase (hTERT) is considered a successful strategy for cancer gene therapy. Polyelectrolyte complexes (PEC) of siRNA and cationic ...
Correlation of inflammatory cytokines with lipid profile in different grades of obesity
[No abstract available]
A Comparison between the cytotoxic effects of pure curcumin and curcumin-loaded PLGA-PEG nanoparticles on the MCF-7 human breast cancer cell line.
Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death among women worldwide. Herbal medicines have tremendous potential as promising agents for the treatment of cancer. Curcumin is a ...
Comparison of inhibitory effects of 17-AAG nanoparticles and free 17-AAG on HSP90 gene expression in breast cancer.
HSP90 may be overexpressed in cancer cells which are greatly dependent on Hsp90 function. Geldanamycin derivative 17 allylamino-17-demethoxygeldanamycin (17-AAG) inhibits the function and expression of HSP90. 17-AAG has ...
The effect of dimethyl sulfoxide on hepatic differentiation of mesenchymal stem cells.
Adipose tissue-derived mesenchymal stem cells (AT-MSCs) are suitable choices in autologous stem cell treatment of liver-associated diseases due to their hepatic differentiation potential. Dimethyl sulfoxide (DMSO) is an ...
Construction and Production of Foxp3-Fc (IgG) DNA Vaccine/Fusion Protein.
It seems that the success of vaccination for cancer immunotherapy such as Dendritic Cell (DC) based cancer vaccine is hindered through a powerful network of immune system suppressive elements in which regulatory T cell is ...
Correlation between leptin serum levels with lipid profile and anthropometric indices in women with different grades of obesity
Background and Objective: Leptin is a 16 KDa peptide which has a close correlation with adiposity. However, its effect on lipid profile is controversial in human. Therefore, this study was performed to investigate correlation ...
Carbon nanotubes: properties, synthesis, purification, and medical applications.
Current discoveries of different forms of carbon nanostructures have motivated research on their applications in various fields. They hold promise for applications in medicine, gene, and drug delivery areas. Many different ...