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Physicochemical analysis and nonisothermal kinetic study of sertraline-lactose binary mixtures.
(2017)
In the present study the physicochemical stability of sertraline with lactose was evaluated in drug-excipient binary mixtures. Different physicochemical methods such as differential scanning calorimetry (DSC), Fourier-transform ...
Development and Optimisation of Spironolactone Nanoparticles for Enhanced Dissolution Rates and Stability.
(2017)
Stable solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) formulations to enhance the dissolution rates of poorly soluble drug spironolactone (SP) were being developed. Probe ultra-sonication method ...
Lower glycemic indices and lipid profile among type 2 diabetes mellitus patients who received novel dose of Silybum marianum (L.) Gaertn. (silymarin) extract supplement: A Triple-blinded randomized controlled clinical trial.
(2018)
This randomized clinical trial was conducted to evaluate the effects of silymarin supplementation on glycemic indices and serum lipid profile in type 2 diabetes mellitus (T2DM) patients.40 T2DM patients (twenty male and ...
Crystal-liquid Fugacity Ratio as a Surrogate Parameter for Intestinal Permeability.
We assessed the feasibility of using crystal-liquid fugacity ratio (CLFR) as an alternative parameter for intestinal permeability in the biopharmaceutical classification (BCS) of passively absorbed drugs.Dose number, ...
Biological activities of Salvia santolinifolia Boiss. A multifunctional medicinal plant
(2016)
Background: Salvia species are used traditionally for treatment of many disorders all around the world. Salvia santolinifolia is a medicinal plant, traditionally used for treatment of inflammation, hypercholesterolemia, ...
Application of Spray Drying Technique for Flowability enhancement of Divalproex Sodium.
(2018)
Tablets and capsules are the most accepted and widely used solid dosage forms in the medical therapy. Flow property of the powders is playing a key role in the various pharmaceutical fields especially in the fomulation of ...
Application of lactobionic acid and nonionic surfactants as solubilizing agents for parenteral formulation of clarithromycin
(2012)
Purpose: The purpose of this paper is to enhance the solubility of clarithromycin (CLR) using nonionic surfactants and some type of acids for preparation of the new formulations. Methods: Myrj 52 and chremophor (2.5 and ...
Biodegradable m-PEG/PCL core-shell micelles: Preparation and characterization as a sustained release formulation for curcumin
(2014)
Purpose: Among the potent anticancer agents, curcumin is known as a very efficacious against many different types of cancer cells, but its clinical applications has been limited because of hydrophobicity, low gastrointestinal ...
Bortezomib-loaded solid lipid nanoparticles: preparation, characterization, and intestinal permeability investigation
(2018)
Bortezomib (BTZ), a proteasome inhibitor, is clinically used for the treatment of multiple myeloma and mantle cell lymphoma via intravenous or subcutaneous administration. Since BTZ has limited intestinal permeability, in ...
Application of response surface methodology in development of sirolimus liposomes prepared by thin film hydration technique
(2013)
The present investigation was aimed to optimize the formulating process of sirolimus liposomes by thin film hydration method. Methods: In this study, a 32 factorial design method was used to investigate the influence of ...