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Anti-bacterial performance of azithromycin nanoparticles as colloidal drug delivery system against different gram-negative and gram-positive bacteria
(2012)
Purpose: Azithromycin (AZI) is a new macrolide antibiotic with a better activity against intracellular gram negative bacteria in comparison with Erythromycin. The purpose of this research was to prepare AZI nanoparticles ...
Application of lactobionic acid and nonionic surfactants as solubilizing agents for parenteral formulation of clarithromycin
(2012)
Purpose: The purpose of this paper is to enhance the solubility of clarithromycin (CLR) using nonionic surfactants and some type of acids for preparation of the new formulations. Methods: Myrj 52 and chremophor (2.5 and ...
Application of response surface methodology in development of sirolimus liposomes prepared by thin film hydration technique
(2013)
The present investigation was aimed to optimize the formulating process of sirolimus liposomes by thin film hydration method. Methods: In this study, a 32 factorial design method was used to investigate the influence of ...
Lower glycemic indices and lipid profile among type 2 diabetes mellitus patients who received novel dose of Silybum marianum (L.) Gaertn. (silymarin) extract supplement: A Triple-blinded randomized controlled clinical trial.
(2018)
This randomized clinical trial was conducted to evaluate the effects of silymarin supplementation on glycemic indices and serum lipid profile in type 2 diabetes mellitus (T2DM) patients.40 T2DM patients (twenty male and ...
Biological activities of Salvia santolinifolia Boiss. A multifunctional medicinal plant
(2016)
Background: Salvia species are used traditionally for treatment of many disorders all around the world. Salvia santolinifolia is a medicinal plant, traditionally used for treatment of inflammation, hypercholesterolemia, ...
Biodegradable m-PEG/PCL core-shell micelles: Preparation and characterization as a sustained release formulation for curcumin
(2014)
Purpose: Among the potent anticancer agents, curcumin is known as a very efficacious against many different types of cancer cells, but its clinical applications has been limited because of hydrophobicity, low gastrointestinal ...
Bortezomib-loaded solid lipid nanoparticles: preparation, characterization, and intestinal permeability investigation
(2018)
Bortezomib (BTZ), a proteasome inhibitor, is clinically used for the treatment of multiple myeloma and mantle cell lymphoma via intravenous or subcutaneous administration. Since BTZ has limited intestinal permeability, in ...
A fast and simple spectrofluorometric method for the determination of alendronate sodium in pharmaceuticals.
(2014)
Alendronate sodium enhances bone formation and increases osteoblast proliferation and maturation and leads to the inhibition of osteoblast apoptosis. Therefore, a rapid and simple spectrofluorometric method has been developed ...
Enhanced cellular internalization of CdTe quantum dots mediated by arginine- and tryptophan-rich cell-penetrating peptides as efficient carriers.
(2016)
Quantum dots (QDs), as a new class of fluorescent tags, have been widely used for biomedical applications. Despite their various advantages, QDs do not efficiently enter cells on their own, and aggregation often occurs ...
Comparative Study of Different Combinational Mucoadhesive Formulations of Sumatriptan-Metoclopramide.
(2016)
Sumatriptan succinate (Sum) is a Serotonin 5- HT1 receptor agonist, used in the treatment of migraine. It is absorbed rapidly but incompletely when taken orally and underwent first - pass metabolism, resulting in a low ...