Now showing items 1-10 of 194
Engineered Mannitol Ternary Additives Improve Dispersion of Lactose-Salbutamol Sulphate Dry Powder Inhalations
The aim of this study was to evaluate the influence of novel engineered fine mannitol particles (4.7%, w/w) on the performance of lactose-salbutamol sulphate dry powder inhaler (DPI) formulations to obtain promising ...
Preparation and characterization of celecoxib dispersions in soluplus(®): comparison of spray drying and conventional methods.
The present study deals with characterization of dispersions of a poorly water-soluble drug, celecoxib (CLX) in polyvinyl caprolactame-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus(®) (SOL)) prepared by ...
Prediction of benzodiazepines solubility using different cosolvency models
The solubility of four benzodiazepines (BZPs) including diazepam (DIZ), lorazepam (LRZ) clonazepam (CLZ), and chlordiazepoxide (CHZ) in water-cosolvent (ethanol propylene glycol and polyethylene glycol 200) binary systems ...
Comparison of acetaminophen with or without codeine to ibuprofen on the postoperative pain of pediatric tonsillectomy
Introduction: Management of pain in children is often inadequate and numerous clinical practice guidelines and policy statements have been published on the subject of pediatric pain. Tonsillectomy is among the most frequent ...
Dry powder inhalers: Mechanistic evaluation of lactose formulations containing salbutamol sulphate
The purpose of this study was to evaluate the relationships between physicochemical properties and aerosolisation performance of different grades of lactose. In order to get a wide range of physicochemical properties, ...
Agglomeration of Celecoxib by Quasi Emulsion Solvent Diffusion Method: Effect of Stabilizer
Purpose: The quasi-emulsion solvent diffusion (QESD) has evolved into an effective technique to manufacture agglomerates of API crystals. Although, the proposed technique showed benefits, such as cost effectiveness, that ...
An approach to controlled-release dosage form of propranolol hydrochloride
It is possible to release a drug with only limited diffusion from a membrane-coated system using osmotic pumping. In this study, a propranolol osmotic pump was produced by coating the core tablets with cellulose acetate. ...
The effects of pH and polarity of electrode on the remaining propranolol within human skin
[No abstract available]
Drug release from matrix tablets: physiological parameters and the effect of food
Introduction: As dissolution plays an important and vital role in the drug-delivery process of oral solid dosage forms, it is, therefore, essential to critically evaluate the parameters that can affect this process. Areas ...
Improvement of physicomechanical properties of carbamazepine by recrystallization at different pH values.
The morphology of crystals has an appreciable impact role on the physicochemical properties of drugs. Drug properties such as flowability, dissolution, hardness and bioavailability may be affected by crystallinity behaviours ...