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BACH1, the master regulator gene: A novel candidate target for cancer therapy.
(2016)
BACH1 (BTB and CNC homology 1, basic leucine zipper transcription factor 1) is a transcriptional factor and a member of cap 'n' collar (CNC) and basic region leucine zipper factor family. In contrast to other bZIP family ...
Mechanisms of immune system activation in mammalians by small interfering RNA (siRNA).
(2016)
RNA interference (RNAi) guided by small interfering RNAs (siRNA), because of its potential to target and silence the expression of specific genes is utilized as an effective tool in a variety of biological applications. ...
Arsenic Trioxide Promotes Paclitaxel Cytotoxicity in Resistant Breast Cancer Cells.
(2015)
A partial response or resistance to chemotherapeutic agents is considered as a main obstacle in treatment of patients with cancer, including breast cancer. Refining taxane-based treatment procedures using adjuvant or ...
Molecular mechanisms of apoptosis and roles in cancer development and treatment.
(2015)
Programmed cell death (PCD) or apoptosis is a mechanism which is crucial for all multicellular organisms to control cell proliferation and maintain tissue homeostasis as well as eliminate harmful or unnecessary cells from ...
Reduced ABCB1 Expression and Activity in the Presence of Acrylic Copolymers.
(2014)
P-glycoprotein (P-gp; ABCB1), an integral membrane protein in the apical surface of human intestinal epithelial cells, plays a crucial role in the intestinal transport and efflux leading to changes in the bioavailability ...
Therapeutic Effects of Myeloid Cell Leukemia-1 siRNA on Human Acute Myeloid Leukemia Cells.
(2014)
Up-regulation of Mcl-1, a known anti-apoptotic protein, is associated with the survival and progression of various malignancies including leukemia. The aim of this study was to explore the effect of Mcl-1 small interference ...
Effect of a combined treatment with erythropoietin and melatonin on renal ischemia reperfusion injury in male rats.
(2014)
Renal ischemia reperfusion (IR) is an important cause of renal dysfunction. It contributes to the development of acute renal failure. Oxidative damage from reactive oxygen species is considered to be the principal component ...
Evaluation of gamma radiation-induced cytotoxicity of breast cancer cells: Is there a time-dependent dose with high efficiency?
Radiotherapy is one of the important treatment modalities in the management of breast cancer.The aim of this study is to study the efficient treatment of breast cancer as related to the dose delivery.The human breast cancer ...
Cloning and Expression of CD19, a Human B-Cell Marker in NIH-3T3 Cell Line.
CD19 is a pan B cell marker that is recognized as an attractive target for antibody-based therapy of B-cell disorders including autoimmune disease and hematological malignancies. The object of this study was to stably ...
Correlation between superoxide dismutase 1 gene expression with lactate dehydrogenase enzyme and free radicals in female athletes: Effects of incremental intensity exercises
(2012)
Background: Inflammatory enzymes and free radicals are important factors affecting the immune system. However, there seems to be no detailed information about the extent to which these factors can affect superoxide dismutase ...