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New insights into the mechanisms of multidrug resistance in cancers
(2015)
Drug resistance is one of the major obstacles in the treatment of various cancers. Since chemotherapy serves as a most beneficial method for the repression of tumor progression and due to its desirable cell death potency ...
Inhibitory and cytotoxic activities of Salvia officinalis l. Extract on human lymphoma and leukemia cells by induction of apoptosis
(2013)
Purpose: Salvia officinalis L., also known as Maryam Goli, is one of the native plants used to Persian medicinal herbs. Hence, the objective of this study was to examine the in vitro cytotoxic activities of a standardized ...
Micro-RNAs: The new potential biomarkers in cancer diagnosis, prognosis and cancer therapy
(2015)
MicroRNAs (miRNAs) are a large class of small noncoding RNAs approximately 22 nucleotides in length. They are the main regulators of gene expression, regulating specific oncogenes, tumor suppressors, cancer stem cells and ...
Topical application of Mentha piperita essential oil accelerates wound healing in infected mice model
(2018)
This study was conducted to evaluate the effects of the prepared ointments from Mentha piperita essential oil (M. piperita) on wound healing in the infected mice models. Each circular full-thickness wound was inoculated ...
Differential effects of peroxisome proliferator-activated receptor agonists on doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells
(2015)
P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) in tumor cells is still a main obstacle for the chemotherapeutic treatment of cancers. Therefore, identification of safe and effective MDR reversing compounds with ...
Cloning and molecular characterization of the cDNAs encoding the variable regions of an anti-CD20 monoclonal antibody
(2017)
BACKGROUND: CD20-based targeting of B-cells in hematologic malignancies and autoimmune disorders is associated with outstanding clinical outcomes. Isolation and characterization of VH and VL cDNAs encoding the variable ...
Urtica dioica Extract Inhibits Proliferation and Induces Apoptosis and Related Gene Expression of Breast Cancer Cells In Vitro and In Vivo.
(2017)
Currently, because the prevalence of breast cancer and its consequent mortality has increased enormously in the female population, a number of studies have been designed to identify natural products with special antitumor ...
Isolation and characterization of anti ROR1 single chain fragment variable antibodies using phage display technique
(2017)
Receptor tyrosine kinase-like orphan receptor (ROR1) belongs to one of the families of receptor tyrosine kinases (RTKs). RTKs are involved in the various physiologic cellular functions including proliferation, migration, ...
Mass-production and characterization of anti-CD20 monoclonal antibody in peritoneum of Balb/c mice
(2013)
Purpose: Monoclonal antibodies are important tools are used in basic research as well as, in diagnosis, imaging and treatment of immunodeficiency diseases, infections and cancers. The purpose of this study was to produce ...
Large scale generation and characterization of anti-human CD34 monoclonal antibody in ascetic fluid of balb/c mice
(2013)
Purpose: Monoclonal antibodies or specific antibodies are now an essential tool of biomedical research and are of great commercial and medical value. The purpose of this study was to produce large scale of monoclonal ...