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Four novel germline mutations in the MLH1 and PMS2 mismatch repair genes in patients with hereditary nonpolyposis colorectal cancer
(2009)
Background: Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common cause of early onset hereditary colorectal cancer. In the majority of HNPCC families, microsatellite instability (MSI) and germline mutation ...
Gastro-oesophageal reflux disease and irritable bowel syndrome: A significant association in an Iranian population
(2008)
Background: Gastro-oesophageal reflux disease and irritable bowel syndrome are common diseases, which may be related. Aim: To assess the association between gastro-oesophageal reflux disease and irritable bowel syndrome ...
Association between MTHFR polymorphism (C677T) with nonfamilial colorectal cancer
(2009)
The enzyme 5,10-methylene-tetrahydrofolate reductase (MTHFR) is linked to DNA methylation, synthesis, and repair. C677T is one of the most important polymorphisms in the MTHFR gene. The single nucleotide polymorphism C677T ...
Relation between demographic factors and hospitalization in patients with gastrointestinal disorders, using quantile regression analysis.
(2009)
OBJECTIVE: The aim of this study is to investigate relation between demographic factors and hospitalization in gastrointestinal disorders. Quantile regression was used to analyze the predictors of duration of staying in ...
Profile and frequency of p53 Gene alterations in gastritis lesions from Iran
(2010)
Background: It has been frequently shown that p53 alterations have an important role in the development of gastric cancers but there is no data on p53 alteration in gastric cancer and its precancerous lesions from Iran ...
Seroepidemiology of hepatitis A and E virus infections in Tehran, Iran: A population based study
(2012)
Hepatitis A virus (HAV) and hepatitis E virus (HEV) are enteric hepatotropic viruses and their prevalence is related to the sanitary conditions of the region under investigation. There are only a few studies on the ...
NOD2 exonic variations in Iranian Crohn's disease patients
(2011)
Purpose The NOD2 gene is known to have a strong association with Crohn's disease, but different trends were reported in occurrence of NOD2 variants in distinct ethnicities. The aim of this study was to assess all exonic ...
Mucins in neoplastic spectrum of colorectal polyps: Can they provide predictions?
(2010)
Background: The significance of expression of different mucins in succession of malignant transformation of colorectal polyps is not determined yet. The aim of the present study was to determine the pattern of expression ...
Improvement of liver function in liver cirrhosis patients after autologous mesenchymal stem cell injection: A phase I-II clinical trial
(2009)
BACKGROUND: End-stage liver disease is a medical problem with high morbidity and mortality. We have investigated the feasibility, safety, and efficacy of using autologous mesenchymal stem cells (MSCs) as a treatment. ...
Impact of EXO1 polymorphism in susceptibility to colorectal cancer
(2010)
Background and Aim: One candidate gene for colorectal cancer (CRC) susceptibility is exonuclease 1 (EXO1). It is a member of RAD2 nuclease family, which plays a major role in mismatch repair, DNA replication, and recombination. ...