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Direct and indirect medical costs of functional constipation: A population-based study
(2011)
Background Constipation causes a large number of medical visits each year and imposes significant financial toll on healthcare systems worldwide. So the present communitybased study was conducted in order to estimate ...
Evaluation of the left-to-right shift of colon tumors in Iran: Is the trend changing?
(2015)
Background: Colorectal cancer (CRC) is the second cause of cancer-related deaths worldwide. There have been several studies reporting the proximal tumor shift, especially in Western countries. In the present study, we ...
Four novel germline mutations in the MLH1 and PMS2 mismatch repair genes in patients with hereditary nonpolyposis colorectal cancer
(2009)
Background: Hereditary nonpolyposis colorectal cancer (HNPCC) is the most common cause of early onset hereditary colorectal cancer. In the majority of HNPCC families, microsatellite instability (MSI) and germline mutation ...
Gastro-oesophageal reflux disease and irritable bowel syndrome: A significant association in an Iranian population
(2008)
Background: Gastro-oesophageal reflux disease and irritable bowel syndrome are common diseases, which may be related. Aim: To assess the association between gastro-oesophageal reflux disease and irritable bowel syndrome ...
Age-specific seroprevalence of hepatitis A infection among children visited in pediatric hospitals of Tehran, Iran
(2004)
Background: Hepatitis A is an enterically transmitted disease that still remains endemic in many developing countries. In some countries improvements in living conditions have recently led to changing in epidemiology of ...
Appendectomy, tonsillectomy, and risk of inflammatory bowel disease: A case control study in Iran
(2006)
There is some controversy about the prevalence of appendectomy and tonsillectomy among patients with Crohn's disease and a lower rate of appendectomy among patients with ulcerative colitis (UC). The objective of this study ...
C77G mutation in protein tyrosine phosphatase CD45 gene and autoimmune hepatitis
(2005)
Autoimmune hepatitis (AIH) is a rare frequent, multiplex disorder with undefined etiology. Susceptibility to autoimmune hepatitis results from complex interactions between genetic and environmental factors. In this study, ...
Association between MTHFR polymorphism (C677T) with nonfamilial colorectal cancer
(2009)
The enzyme 5,10-methylene-tetrahydrofolate reductase (MTHFR) is linked to DNA methylation, synthesis, and repair. C677T is one of the most important polymorphisms in the MTHFR gene. The single nucleotide polymorphism C677T ...
Association between insulin receptor gene exon 17 rs1799817 variant and risk of nonalcoholic fatty liver disease
(2017)
Background and objectives Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease characterized by accumulation of triglycerides in hepatocytes without alcohol consumption. Considering the key ...
Association of vitamin D receptor gene polymorphisms in Iranian patients with inflammatory bowel disease
(2008)
Background and Aims: The vitamin D receptor (VDR) gene maps to a region on chromosome 12 shown to be linked to inflammatory bowel disease (IBD). Many studies have recognized the relation of VDR gene polymorphisms with ...